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Galleria mellonella and the Study of Fungal Pathogenesis: Making the Case for Another Genetically Tractable Model Host

  • Guest Editorial to Mowlds and Kavanagh (DOI 10.1007/s11046-007-9069-9)
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References

  1. Mylonakis E, Casadevall A, Ausubel FM. Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi. PLoS Pathog 2007;3(7):e101.

    Article  PubMed  CAS  Google Scholar 

  2. Casadevall A. Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection? Fungal Genet Biol 2005;42(2):98–106.

    Article  PubMed  Google Scholar 

  3. Steenbergen JN, Nosanchuk JD, Malliaris SD, Casadevall A. Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii. Infect Immun 2004;72(6):3478–88.

    Article  PubMed  CAS  Google Scholar 

  4. Cotter G, Doyle S, Kavanagh K. Development of an insect model for the in vivo pathogenicity testing of yeasts. FEMS Immunol Med Microbiol 2000;27(2):163–9.

    Article  PubMed  CAS  Google Scholar 

  5. Brennan M, Thomas DY, Whiteway M, Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunol Med Microbiol 2002;34(2):153–7.

    Article  PubMed  CAS  Google Scholar 

  6. Bergin D, Brennan M, Kavanagh K. Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella. Microbes Infect 2003;5(15):1389–95.

    Article  PubMed  Google Scholar 

  7. Mylonakis E, Moreno R, El Khoury JB, et al. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun 2005;73(7):3842–50.

    Article  PubMed  CAS  Google Scholar 

  8. London R, Orozco BS, Mylonakis E. The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host–pathogen interactions. FEMS Yeast Res 2006;6(4):567–73.

    Article  PubMed  CAS  Google Scholar 

  9. St Leger RJ, Screen SE, Shams-Pirzadeh B. Lack of host specialization in Aspergillus flavus. Appl Environ Microbiol 2000;66(1):320–4.

    Article  Google Scholar 

  10. Reeves EP, Messina CG, Doyle S, Kavanagh K. Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella. Mycopathologia 2004;158(1):73–9.

    Article  PubMed  CAS  Google Scholar 

  11. Kavanagh K, Reeves EP. Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens. FEMS Microbiol Rev 2004;28(1):101–12.

    Article  PubMed  CAS  Google Scholar 

  12. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86(6):973–83.

    Article  PubMed  CAS  Google Scholar 

  13. Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell 2004;3(2):413–9.

    Article  PubMed  CAS  Google Scholar 

  14. Alarco AM, Marcil A, Chen J, Suter B, Thomas D, Whiteway M. Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. J Immunol 2004;172(9):5622–8.

    PubMed  CAS  Google Scholar 

  15. Bergin D, Reeves EP, Renwick J, Wientjes FB, Kavanagh K. Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils. Infect Immun 2005;73(7):4161–70.

    Article  PubMed  CAS  Google Scholar 

  16. Mowlds P, Kavanagh K. Effect of pre-incubation temperature on susceptibility of Galleria mellonella larvae to infection by Candida albicans. Mycopathologia [Epub ahead of print] 6 oct 2007.

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Authors and Affiliations

  1. Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Gray 5, GRJ-504, Boston, MA, 02114, USA

    Eleftherios Mylonakis

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  1. Eleftherios Mylonakis
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Correspondence to Eleftherios Mylonakis.

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Mylonakis, E. Galleria mellonella and the Study of Fungal Pathogenesis: Making the Case for Another Genetically Tractable Model Host. Mycopathologia 165, 1–3 (2008). https://doi.org/10.1007/s11046-007-9082-z

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