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Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy

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Abstract

One of the most characteristic features of the chromoblastomycosis is its unresponsiveness to treatment. In order to analyzed whether during therapy could be observed a change of cellular immune response pattern, we evaluated the production of IL-10, TNF-α and IFN-γ, as well as proliferation of peripheral blood mononuclear cell (PBMC) from patients in different periods of chemotherapy treatment. Our results showed that after 6 months of treatment cells from patients proliferated to fungal antigens and produced a significant level of IFN-γ. However, after 1 year of treatment a low proliferation of T cells and production of IFN-γ accompanied by an increase of IL-10 were observed when compared with 6 months of treatment.

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Authors and Affiliations

  1. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 17, São Paulo, CEP: 05508-900, Brazil

    Viviane Mazo Fávero Gimenes & Sandro Rogério Almeida

  2. Departamento de Dermatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Paulo Ricardo Criado & José Eduardo Costa Martins

Authors
  1. Viviane Mazo Fávero Gimenes
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  2. Paulo Ricardo Criado
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  3. José Eduardo Costa Martins
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  4. Sandro Rogério Almeida
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Correspondence to Sandro Rogério Almeida.

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Gimenes, V.M.F., Criado, P.R., Martins, J.E.C. et al. Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy. Mycopathologia 162, 97–101 (2006). https://doi.org/10.1007/s11046-006-0041-x

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  • DOI: https://doi.org/10.1007/s11046-006-0041-x

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