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Evaluation of Fusarium solani Hyphae and Conidia Susceptibility to Amphotericin B and Itraconazole: Study of a Clinical Case

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Abstract

Fusarium species are hyaline moulds belonging to the hyalohyphomycosis group that are usually found in the soil and plants. This organism has emerged as a cause of disseminated invasive disease. The correlation between in vitro value and clinical efficacy is low and many patients remain unresponsive to treatment despite in vitro susceptibility. We determined growth control for Fusarium solani using the BioCell-Tracer® system that measures the growth rate of a single fungal hypha, and the effect of different concentrations of amphotericin B and itraconazole. The MIC for these two drugs was also determined by a broth microdilution technique, using RPMI 1640. Different MICs for amphotericin B were obtained by the two different methods. This paper describes a case of infection due to Fusarium solani in an allogeneic bone marrow transplanted patient, the microbiological diagnostic, antifungal susceptibility tests for conidia and hypha and clinical correlation.

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Authors and Affiliations

  1. Clinical Pathology Department, State University of Campinas, São Paulo, Brazil

    A. B. A. Teixeira, A. von Nowakonski & A. Z. Schreiber

  2. Infectious Diseases Division, State University of Campinas, São Paulo, Brazil

    M. L. Moretti, P. Trabasso & F. H. Aoki

  3. Hematology Division, School of Medical Sciences, State University of Campinas, São Paulo, Brazil

    A. C. Vigorito

  4. Research Center for Pathogenic Fungi and Microbial Toxicosis, Chiba University, Japan

    M. Miyaji, K. Nishimura & H. Taguchi

  5. Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas – UNICAMP, Cidade Universitária Zeferino Vaz, Cx, Campinas, São Paulo, CEP 13083-970, Postal 6142, Brazil

    A. Z. Schreiber

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  1. A. B. A. Teixeira
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  2. M. L. Moretti
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  3. P. Trabasso
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  4. A. von Nowakonski
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  5. F. H. Aoki
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  6. A. C. Vigorito
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  7. M. Miyaji
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  8. K. Nishimura
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  9. H. Taguchi
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  10. A. Z. Schreiber
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Correspondence to A. Z. Schreiber.

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Teixeira, A.B.A., Moretti, M.L., Trabasso, P. et al. Evaluation of Fusarium solani Hyphae and Conidia Susceptibility to Amphotericin B and Itraconazole: Study of a Clinical Case. Mycopathologia 160, 291–296 (2005). https://doi.org/10.1007/s11046-005-0106-2

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  • DOI: https://doi.org/10.1007/s11046-005-0106-2

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