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Natural polyphenols: a promising bioactive compounds for skin care and cosmetics

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Abstract

The physiological and morphological aspects of skin suffer from frequent change. Numerous internal and external factors have direct impact on inducing various skin problems like inflammation, aging, cancer, oxidative stress, hyperpigmentation etc. The use of plant polyphenols as a photo-ecting agent is gaining popularity nowadays. Polyphenols are known to enhance endogenic antioxidant system of skin thereby preventing various skin diseases. The biological activity of plant polyphenols is dependent on their physicochemical properties for overcoming the epidermal barriers to reach the specific receptor. Several evidences have reported the vital role polyphenols in mitigating adverse skin problems and reverting back the healthy skin condition. The interest in plant derived skin care products is emerging due to the changing notion of people to shift their focus towards use of plant-based products. The present review draws an attention to uncover the protective role of polyphenols in prevention of various skin problems. Several in vitro and in vivo studies have been summarized that claims the efficacious nature of plant extract having dermatological significance.

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Abbreviations

MMP:

Matrix metalloproteinase

UV rays:

Ultraviolet rays

ROS:

Reactive oxygen species

EGCG:

Epigallo catechin-3-gallate

NO:

Nitric oxide

H2O2 :

Hydrogen peroxide

COX-2:

Cyclooxygenase-2

GTP:

Green tea polyphenol

EC:

Epicatechin

ECG:

(-) Epicatechin-3-gallate

IL:

Interleukin

TNF:

Tumor necrosis factor

MAPK:

Mitogen-activated protein kinase

iNOS:

Inducible nitric oxide synthase

TGF:

Transforming growth factor

AP-1:

Activator protein 1

HaCaT:

Human keratinocyte cell culture

TGM:

Transglutaminase

FLG:

Filaggrin gene

HAS:

Hyaluronic acid synthase

MPO:

Myeloperoxidase

SOD:

Superoxide dismutase

CAT:

Catalase

TRP:

Tyrosinase related protein

DNA:

Deoxyribonucleic acid

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  1. Plant Biotechnology Laboratory, Department of Biotechnology, Delhi Technological University, Delhi, 110042, India

    Navneeta Bharadvaja, Shruti Gautam & Harshita Singh

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  1. Navneeta Bharadvaja
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  2. Shruti Gautam
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Correspondence to Navneeta Bharadvaja.

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Bharadvaja, N., Gautam, S. & Singh, H. Natural polyphenols: a promising bioactive compounds for skin care and cosmetics. Mol Biol Rep 50, 1817–1828 (2023). https://doi.org/10.1007/s11033-022-08156-9

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