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The role of microRNAs in diseases and related signaling pathways

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Abstract

MicroRNAs (miRNAs) are epigenetic regulators of the gene expression and act through posttranslational modification. They bind to 3′-UTR of target mRNAs to inhibit translation or increase the degradation mRNA in many tissues. Any alteration in the level of miRNA expression in many human diseases indicates their involvement in the pathogenesis of many diseases. On the other hand, the regulation of the signaling pathways is necessary for the maintenance of natural and physiological characteristics of any cell. It is worth mentioning that dysfunction of the signaling pathways manifests itself as a disorder or disease. The significant evidence report that miRNAs regulate the several signaling pathways in many diseases. Base on previous studies, miRNAs can be used for therapeutic or diagnostic purposes. According to the important role of miRNAs on the cell signaling pathways, this article reviews miRNAs involvement in incidence of diseases by changing signaling pathways.

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Acknowledgements

This study was supported by the Research Deputy of Arak University of Medical Sciences.

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Authors and Affiliations

  1. Department of Biotechnology and Molecular Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arāk, Iran

    Atena Vaghf & Mahdieh Mondanizadeh

  2. Department of Microbiology and Immunology, Arak University of Medical Sciences, Arāk, Iran

    Behzad Khansarinejad

  3. Department of Medical Laboratory Sciences, Arak School of Paramedicine, Arak University of Medical Sciences, Arāk, Iran

    Ehsanollah Ghaznavi-Rad

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  1. Atena Vaghf
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  3. Ehsanollah Ghaznavi-Rad
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  4. Mahdieh Mondanizadeh
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Correspondence to Mahdieh Mondanizadeh.

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Vaghf, A., Khansarinejad, B., Ghaznavi-Rad, E. et al. The role of microRNAs in diseases and related signaling pathways. Mol Biol Rep 49, 6789–6801 (2022). https://doi.org/10.1007/s11033-021-06725-y

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