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CCR3 gene overexpression in patients with Down syndrome

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Abstract

Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C–C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms. The present study aimed to evaluate the expression of the CCR3 gene by NGS and qRT-PCR in patients with DS and normal controls (NC). The CCR3 gene was over-expressed in DS patients compared to NC. These data suggest that an over-expression of the CCR3 gene is associated with the phenotype of patients with DS.

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Author notes

  1. Michele Salemi and Rossella Cannarella have equally contributed to this article.

Authors and Affiliations

  1. Oasi Research Institute-IRCCS, Troina, EN, Italy

    Michele Salemi, Maria Grazia Salluzzo, Concetta Barone, Salvatore Caniglia, Alda Ragalmuto & Corrado Romano

  2. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

    Rossella Cannarella, Roberto Castiglione & Aldo E. Calogero

  3. Genomix4Life Srl, Baronissi, SA, Italy

    Giovanna Marchese, Maria Ravo & Angela Cordella

Authors
  1. Michele Salemi
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  2. Rossella Cannarella
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  3. Giovanna Marchese
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  4. Maria Grazia Salluzzo
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  5. Maria Ravo
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  6. Concetta Barone
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  7. Angela Cordella
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  8. Salvatore Caniglia
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  9. Roberto Castiglione
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  10. Alda Ragalmuto
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  11. Aldo E. Calogero
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  12. Corrado Romano
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Contributions

MS, RC, AEC, GM, MR, CB and CR planned the study. MS, MGS, AC, SC, RC and AR performed experiments and analysed data. All authors edited the manuscript.

Corresponding author

Correspondence to Michele Salemi.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved on 3 June 2017 by the local IRB (2017/05/31/CE-IRCCS-OASI/9).

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All the study participants, or their legal guardians, signed an informed consent to publish.

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Salemi, M., Cannarella, R., Marchese, G. et al. CCR3 gene overexpression in patients with Down syndrome. Mol Biol Rep 48, 5335–5338 (2021). https://doi.org/10.1007/s11033-021-06503-w

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  • DOI: https://doi.org/10.1007/s11033-021-06503-w

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