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Physical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis

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Abstract

Neutrophil extracellular traps (NETs) represent an innate organism defense mechanism characterized by neutrophil release of intracellular material to capture any aggressor agent. Elevated NETs release is associated with increased inflammatory response and related diseases, such as obesity. Chronic physical training is one of the main strategies to treat and prevent obesity. The relationship between physical training and NETs is still under study. The present review, followed by a bioinformatics analysis, demonstrates the meaningful connection between physical exercise, obesity, and NETs. The bioinformatics indicated TNF-α as a leading gene after the ontological analysis followed by positive-interleukin-6 regulation, chemokines, and inflammatory response regulation. The main results pointed to a relevant regulatory effect of physical training on NETs release, indicating physical exercise as a possible therapeutic target on modulating NETs and inflammation.

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Funding

This work was partially supported by grants from Coordenadoria de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG).

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  1. Laboratory of Health Science, Postgraduate Program in Health Sciences, State University of Montes Claros, Montes Claros, MG, Brazil

    Berenilde Valeria Oliveira de Sousa, Daniela Fernanda de Freitas, Renato Sobral Monteiro-Junior, Iara Heloisa Ramos Mendes, Jaciara Neves Sousa, Victor Hugo Dantas Guimarães & Sérgio Henrique Sousa Santos

  2. Departments of Food Engineering, Institute of Agriculture Sciences, Federal University of Minas Gerais, Montes Claros, MG, Brazil

    Sérgio Henrique Sousa Santos

  3. State University of Montes Claros (UNIMONTES), Montes Claros, MG, Brazil

    Berenilde Valeria Oliveira de Sousa

  4. Laboratory of Health Science, Universidade Estadual de Montes Claros, Av. Cula Mangabeira 562, Montes Claros, MG, 31401-001, Brazil

    Sérgio Henrique Sousa Santos

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  1. Berenilde Valeria Oliveira de Sousa
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  2. Daniela Fernanda de Freitas
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BS: conceptualization, methodology, writing—original draft. DF, RMJ, IM, JS, VG: writing—original draft. SS: conceptualization, writing—review & editing, Supervision.

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Correspondence to Sérgio Henrique Sousa Santos.

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Valeria Oliveira de Sousa, B., de Freitas, D.F., Monteiro-Junior, R.S. et al. Physical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis. Mol Biol Rep 48, 4625–4635 (2021). https://doi.org/10.1007/s11033-021-06400-2

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