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High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer

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Abstract

Long intergenic non-coding RNA for kinase activation (Linc-A) has been reported to enhance the occurrence and progression of breast cancer. Nevertheless, whether Linc-A is related to the tumorigenesis of colorectal cancer (CRC) remains unknown. In this study, we aimed to evaluate the expression of Linc-A in colon adenocarcinoma and explore the correlation between Linc-A and prognosis of CRC. The expression of Linc-A in human colon tissues was evaluated by qRT-PCR, which contained 15 pairs of human colon adenocarcinoma and paracancerous tissues and other 65 colon adenocarcinoma tissues. A total of 80 patients were divided into low and high expression groups according to the Linc-A levels. The levels of Linc-A in colon adenocarcinoma was higher than that in paracancerous tissues (p = 0.047). Furthermore, high expression of Linc-A was associated with advanced TNM stage (p = 0.013), positive lymph nodes (p = 0.024), low 5-year survival rate (p = 0.024) and even 10-year survival rate (p = 0.007). Besides, Linc-A, advanced age, advanced TNM stage, deep infiltration degree and positive lymph nodes were also found to be positively related to poor overall 5-year survival by Kaplan–Meier survival analysis(p < 0.05). Then, multivariable Cox regression analysis revealed that Linc-A was an independent risk factor for prognosis of colon adenocarcinoma (p = 0.047). In conclusion, high expression of Linc-A is associated with advanced TNM stage, lymphatic metastasis and poor survival in patients with CRC. Linc-A may be served as a candidate prognostic biomarker for CRC.

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Acknowledgements

This study is supported by Natural Science Fund of China (U1702281, 81670551 and 81873584), National Key R&D Program of China (2017YFA0205404). The abstract has been presented in 26th United European Gastroenterology Week Vienna 2018 as a poster.

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Authors and Affiliations

  1. Lab of Gastroenterology and Hepatology, West China Hospital, Sichuan University, NO. 1, 4th Keyuan Road, Chengdu, 610041, People’s Republic of China

    Chong Zhao, Yang Xiao, Rui Liu, Chengwei Tang & Jinhang Gao

  2. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China

    Chong Zhao, Can Gan, Yang Xiao, Rui Liu, Linhao Zhang, Tian Lan, Yanting Ye, Huan Tong, Zhiyin Huang, Chengwei Tang & Jinhang Gao

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  1. Chong Zhao
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  2. Can Gan
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  3. Yang Xiao
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Correspondence to Jinhang Gao.

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Zhao, C., Gan, C., Xiao, Y. et al. High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer. Mol Biol Rep 47, 7497–7504 (2020). https://doi.org/10.1007/s11033-020-05809-5

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