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The roles of non-coding RNAs in Parkinson’s disease

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Abstract

Parkinson’s disease (PD) is considered as a high prevalence neurodegenerative disorders worldwide. Pathologically, the demise of dopamine-producing cells, in large part due to an abnormal accumulation of the α-synuclein in the substantia nigra, is one of the main causes of the disease. Up until now, many de novo investigations have been conducted to disclose the mechanisms underlying in PD. Among them, impacts of non-coding RNAs (ncRNAs) on the pathogenesis and/or progression of PD need to be highlighted. microRNAs (miRNAs) and long ncRNAs (lncRNAs) are more noteworthy in this context. miRNAs are small ncRNAs (with 18–25 nucleotide in length) that control the expression of multiple genes at post-transcriptional level, while lncRNAs have longer size (over 200 nucleotides) and are involved in some key biological processes through various mechanisms. Involvement of miRNAs has been well documented in the development of PD, particularly gene expression. Hence, in this current review, we will discuss the impacts of miRNAs in regulation of the expression of PD-related genes and the role of lncRNAs in the pathogenesis of PD.

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Authors and Affiliations

  1. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Maryam Majidinia, Aynaz Mihanfar & Alireza Nourazarian

  2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi & Alireza Nourazarian

  3. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran

    Alireza Nourazarian

  4. Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey

    BakiyeGoker Bagca & Çığır Biray Avci

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  5. BakiyeGoker Bagca
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  6. Çığır Biray Avci
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Correspondence to Alireza Nourazarian or Çığır Biray Avci.

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Majidinia, M., Mihanfar, A., Rahbarghazi, R. et al. The roles of non-coding RNAs in Parkinson’s disease. Mol Biol Rep 43, 1193–1204 (2016). https://doi.org/10.1007/s11033-016-4054-3

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  • DOI: https://doi.org/10.1007/s11033-016-4054-3

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