Abstract
This paper describes a case–control study and a meta-analysis performed to evaluate if the following polymorphisms are associated with presence of obesity: −3826A/G (UCP1); −866G/A, Ala55Val and Ins/Del (UCP2) and −55C/T (UCP3). The case–control study enrolled 282 obese and 483 non-obese patients with type 2 diabetes. A literature search was made to identify all studies that evaluated associations between UCP1–3 polymorphisms and obesity. In the case–control study the distributions of the UCP variants did not differ between obese and non-obese groups (P > 0.05). Forty-seven studies were eligible for the meta-analysis and the results showed that the UCP2 −866G/A and UCP3 −55C/T polymorphisms were associated with protection to obesity in Europeans (OR = 0.89, 95 % CI 0.82–0.97 and OR = 0.88, 95 % CI 0.80–0.97, respectively). The UCP2 Ala55 val polymorphism was associated with obesity in Asians (OR = 1.61, 95 % CI 1.13–2.30). The UCP2 Ins/Del polymorphism was associated with obesity mainly in Europeans (OR = 1.19, 95 % CI 1.00–1.42). There was no significant association of the UCP1 −3826A/G polymorphism with obesity. In our case–control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 −866G/A, Ins/Del, Ala55Val and UCP3 −55C/T polymorphisms with obesity.
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Acknowledgments
The authors thank Dra. Caroline Kaercher Kramer for her support with statistical analyses. This study was partially supported by grants from the Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and the Fundo de Incentivo a Pesquisa e Eventos (FIPE) at the Hospital de Clínicas de Porto Alegre. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
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de Almeida Brondani, L., de Souza, B.M., Assmann, T.S. et al. Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis. Mol Biol Rep 41, 5053–5067 (2014). https://doi.org/10.1007/s11033-014-3371-7
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DOI: https://doi.org/10.1007/s11033-014-3371-7