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Association of microparticles and preeclampsia

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Abstract

Preeclampsia (PE) is a syndrome characterized by poor placentation and endothelial dysfunction. The diagnosis for this syndrome is based in hypertension and proteinuria presented after the 20th week of pregnancy. Despite intensive research, PE is still one of the leading causes of maternal mortality, although reliable screening tests or effective treatments of this disease have yet to be proposed. Microparticles (MPs) are small vesicles released after cell activation or apoptosis, which contain membrane proteins that are characteristic of the original parent cell. MPs have been proven to play key role in thrombosis, inflammation, and angiogenesis, as well as to mediate cell–cell communication by transferring mRNAs and microRNA from the cell of origin to target cells. Placenta-derived syncytiotrophoblast MPs are one of the most increased MPs during PE and may play an important role in the pathogenesis of this syndrome. Therefore, a better overall understanding of the role of MPs in PE may be useful for new clinical diagnoses and therapeutic approaches.

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Acknowledgments

CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and FIOCRUZ (Fundação Oswaldo Cruz) for the financial support. The authors also thank the Program for Technological Development in Tools for Health-PDTIS-FIOCRUZ for use of its facilities. A.T.C. and L.M.S.D. are greatful for CNPq fellowship.

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Authors and Affiliations

  1. Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Fabiana K. Marques & Karina B. Gomes

  2. Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil

    Fernanda M. F. Campos & Andréa Teixeira-Carvalho

  3. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil

    Lirlândia P. Sousa, Luci M. S. Dusse & Karina B. Gomes

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  1. Fabiana K. Marques
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Correspondence to Karina B. Gomes.

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Marques, F.K., Campos, F.M.F., Sousa, L.P. et al. Association of microparticles and preeclampsia. Mol Biol Rep 40, 4553–4559 (2013). https://doi.org/10.1007/s11033-013-2536-0

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