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Significance of Tumor Necrosis factor α-308 (G/A) gene polymorphism in the development of prostate cancer

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Abstract

Prostate cancer (PCa) is the most common noncutaneous cancer among men, accounting for 10 % of male cancer-related deaths worldwide. The etiology of PCa is largely unknown, although multiple environmental and lifestyle factors such as ultraviolet irradiation, smoking, and diet might increase the risk of the disease. Risk of disease varies most prominently with age, ethnicity, family history, and diet. The multifunctional cytokine tumor necrosis factor alpha (TNF-α) has an important role in the pathogenesis of inflammatory, autoimmune and malignant diseases. In this case control study 150 Prostate cancer patients and 150 age matched benign prostate hyperplasia (BPH) and equal number of healthy control groups were involved. The aim of this study was to analyze the effect of TNF-α-308 (G/A) polymorphism on risk of prostate cancer on north Indian prostate cancer patients. The polymerase chain reaction (PCR) technique was utilized to genotype TNF-α-308 (G/A) polymorphism. The present study showed statistically significant increased risk of prostate cancer among individuals that carried the A allele of TNF-α-308 gene (OR = 1.81, 95 % CI 1.00–3.481, p = 0.03).

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Acknowledgments

The authors of this article are very much thankful to clinical and non clinical staffs at the Department of Urology in all the three respective hospitals for providing samples and valuable data without which this work would have not been possible.

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Authors and Affiliations

  1. Department of Biotechnology, University of Gondar, Gondar, Ethiopia

    Nega Berhane

  2. Department of Biotechnology, Panjab University, Chandigarh, India

    Rabinder Chandera Sobti & Salih Abdul Mahdi

  3. Department of Mathematics, University of Gondar, Gondar, Ethiopia

    Shiferaw Melesse

  4. Department of Parasitology, Immunology and Microbiology, University of Gondar, Gondar, Ethiopia

    Afework Kassu

Authors
  1. Nega Berhane
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  2. Rabinder Chandera Sobti
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  3. Shiferaw Melesse
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  4. Salih Abdul Mahdi
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  5. Afework Kassu
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Correspondence to Nega Berhane.

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Berhane, N., Sobti, R.C., Melesse, S. et al. Significance of Tumor Necrosis factor α-308 (G/A) gene polymorphism in the development of prostate cancer. Mol Biol Rep 39, 11125–11130 (2012). https://doi.org/10.1007/s11033-012-2020-2

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  • DOI: https://doi.org/10.1007/s11033-012-2020-2

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