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T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer

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Abstract

T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) is a novel transmembrane protein that is involved in the regulation of T-helper 1 cell-mediated immunity. Studies have shown that polymorphisms in TIM-3 gene can be associated with various diseases. Here, we investigated the correlation of TIM-3 polymorphisms with susceptibility to pancreatic cancer in the Chinese population. Three polymorphisms in TIM-3 gene (−1516G/T, −574G/T, and +4259T/G) were identified by polymerase chain reaction–restriction fragment length polymorphism in 306 pancreatic patients and 408 healthy controls. Results showed that the prevalence of +4259TG genotype and +4259G allele were significantly increased in the pancreatic cancer cases than in controls [odds ratio (OR) = 2.82, 95 % confidence interval (CI), 1.45–5.48, p = 0.0015, and OR = 2.74, 95 % CI, 1.42–2.94, p = 0.0017]. In addition, when analyzing the TIM-3 polymorphisms with different clinical parameters in pancreatic cancer patients, the cases with vascular infiltration had higher numbers of +4259T/G polymorphism than those without vascular infiltration (OR = 3.07, 95 % CI, 1.41–6.68, p = 0.003). These results suggested polymorphisms in TIM-3 gene could be new risk factors for the development of pancreatic cancer.

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No competing financial interests exist.

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Authors and Affiliations

  1. Department of Surgery, The Sixth People’s Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, 200233, China

    Danian Tong, Wei Chen, Zhenyi Jia & Dachuan Qi

  2. School of Occupational Therapy, Western University, London, ON, N6G 1H1, Canada

    Yujia Zhou

  3. Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, 200025, China

    Yang Deng & Lei Li

Authors
  1. Danian Tong
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  2. Yujia Zhou
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  3. Wei Chen
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  4. Yang Deng
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  5. Lei Li
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  6. Zhenyi Jia
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  7. Dachuan Qi
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Correspondence to Dachuan Qi.

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Danian Tong and Yujia Zhou contributed equally to this study.

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Tong, D., Zhou, Y., Chen, W. et al. T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer. Mol Biol Rep 39, 9941–9946 (2012). https://doi.org/10.1007/s11033-012-1862-y

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  • DOI: https://doi.org/10.1007/s11033-012-1862-y

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