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TNF promoter −308 A/G and −238 A/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis

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Abstract

The aim of this study was to determine whether the tumor necrosis factor (TNF) promoter polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA). A meta-analysis was conducted on the A allele of the TNF −308 A/G and −238 A/G polymorphisms. The nine comparison studies including 1,132 JIA patients and 1,663 controls were included in the meta-analysis and consisted of 7 European, 1 Mexican, and 1 Turkish population. No association was found between JIA and the TNF −308 A allele and the TNF −238 A allele (odds ratio [OR] = 1.211, 95 % confidence interval [CI] = 0.917–1.598, P = 0.177; OR = 1.135, 95 % CI = 0.603–1.861, P = 0.615, respectively). Stratification by ethnicity did not show the association of the TNF −308 and −238 polymorphisms with JIA in Europeans. Mexicans were found to have lower prevalences of A alleles (2.9, 4.1 %) of the TNF −308 A/G and −238 A/G polymorphisms than any other population studied, and the Turkish population the highest (31.2, 26.9 %). This meta-analysis shows no association between the A alleles of the TNF −308 A/G or −238 A/G polymorphisms and JIA in Europeans, but that the prevalences of these alleles are ethnicity dependent.

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Acknowledgments

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065).

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee & Gwan Gyu Song

  2. Hanyang University Medical Center, Seoul, Korea

    Sang-Cheol Bae

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  1. Young Ho Lee
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  2. Sang-Cheol Bae
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  3. Gwan Gyu Song
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Correspondence to Young Ho Lee.

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Lee, Y.H., Bae, SC. & Song, G.G. TNF promoter −308 A/G and −238 A/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis. Mol Biol Rep 39, 8497–8503 (2012). https://doi.org/10.1007/s11033-012-1704-y

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  • DOI: https://doi.org/10.1007/s11033-012-1704-y

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