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Metabolomics in the fields of oncology: a review of recent research

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Abstract

The study of all endogenously produced metabolites, known as metabolomics, is the youngest of the “omics” sciences. It is becoming increasingly clear that, of all of the “omics” techniques, metabolomic approaches will become increasingly useful in disease diagnosis and have potential power to improve our understanding of the underlying mechanisms of cancer. The primary aim of the review is to discuss the relationship between metabolomics and tumors are elucidated in detail. Then the review is also to introduce the technologies of metabolomics, especially emphasizing the application of metabolomics in the fields of oncology.

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Abbreviations

GC–MS:

Gas chromatography–mass spectrometry

LC–MS:

Lipid chromatography–mass spectrometry

ICP-MS:

Inductively coupled plasma mass spectrometry

FT-MS:

Fourier-transform mass spectrometry

NMR:

Nuclear magnetic resonance

FT-IR:

Fourier-transform infrared spectrometry

TLC:

Thin-layer chromatography

HCC:

Human hepatocellular carcinoma

5-FU:

5-Fluoropyrimidine

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Acknowledgments

This work was financially sponsored by the Shanghai Rising-Star Program (No. 11QA1404800), the Grants from the National Natural Science Foundation of China (No. 81001069), and the National 863 High Technology Foundation (No. 2009AA02Z118).

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Authors and Affiliations

  1. Department of Surgery, Shanghai Tenth People’s Hospital Affiliated to Tongji University, Shanghai, 200072, P. R. China

    Yanlei Ma, Peng Zhang, Yongzhi Yang, Feng Wang & Huanlong Qin

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  1. Yanlei Ma
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  2. Peng Zhang
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Correspondence to Yanlei Ma or Huanlong Qin.

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Ma, Y., Zhang, P., Yang, Y. et al. Metabolomics in the fields of oncology: a review of recent research. Mol Biol Rep 39, 7505–7511 (2012). https://doi.org/10.1007/s11033-012-1584-1

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