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Interleukin-17 contributes to cardiovascular diseases

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Abstract

Interleukin (IL)-17 (also known as IL-17A), as the signature cytokine of the newly described T helper 17 (Th17) cell population, is the founding member of a new subclass of cytokines that have highly proinflammatory properties. Recently there is accumulating evidence that stipulates the involvement of IL-17 in the pathogenesis of cardiovascular diseases via amplifying the inflammation induced by other cytokines in synergistic interactions. The present review provides a summary of the potential roles of IL-17 in the context derived from both animal models and clinical settings in cardiovascular diseases, and perspectives for IL-17-targeted cytokine therapy.

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Acknowledgment

This work was supported in part by the National Natural Science Foundation of China (Grant No. 81170133) and the Natural Science Foundation of Hubei Province, China (Grant No. 2011CDB179).

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Authors and Affiliations

  1. Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, 443000, Hubei Province, China

    Hua-Sheng Ding, Jun Yang, Jian Yang & Jia-Wang Ding

  2. Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, 443000, Hubei Province, China

    Hua-Sheng Ding, Jun Yang, Jian Yang & Jia-Wang Ding

  3. Department of Emergency, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, 443000, Hubei Province, China

    Ping Chen

  4. Department of Nephrology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, 443000, Hubei Province, China

    Ping Zhu

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  1. Hua-Sheng Ding
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  2. Jun Yang
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  3. Jian Yang
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  4. Jia-Wang Ding
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Correspondence to Jun Yang.

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Ding, HS., Yang, J., Yang, J. et al. Interleukin-17 contributes to cardiovascular diseases. Mol Biol Rep 39, 7473–7478 (2012). https://doi.org/10.1007/s11033-012-1580-5

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