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Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case–control studies

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Abstract

Evidence suggested that interleukin-10 (IL-10) may be involved in the etiology of gastric cancer (GC). However, epidemiological studies on the association between IL-10-1082 promoter polymorphism and GC risk are still ambiguous. To quantitatively summarize the evidence for such a relationship, we performed a meta-analysis. Systemic searches of the PubMed and Medline databases were performed, with the last report up to July 2011. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. 22 independent studies including 4,289 cases and 5,965 controls were involved in this meta-analysis. Obvious association was found when all studies were pooled into the meta-analysis (A vs. G: OR = 0.489, 95% CI = 0.335–0.713, P < 0.001). In the subgroup analysis by ethnicity, we observed significant associations in Asians (A vs. G: OR = 0.651, 95% CI = 0.506–0.838, P = 0.001; AA vs. GG: OR = 0.482, 95% CI = 0.328–0.709, P < 0.001; AA/AG vs. GG: OR = 0.711, 95% CI = 0.527–0.959, P = 0.025; AA vs. AG/GG: OR = 0.701, 95% CI = 0.520–0.944, P = 0.019) and Caucasians (A vs. G: OR = 0.365, 95% CI = 0.140–0.949, P = 0.039), but not in Latino population. When stratified analysis by control sources, our results indicated that A allele decreased approximately 48% risk among population-based studies (A vs. G: OR = 0.524, 95% CI = 0.374–0.733, P < 0.001). Taken together, this meta-analysis suggests that IL-10-1082 polymorphism is associated with GC risk.

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Acknowledgments

This work was granted by Anhui Provincial Science and Technology Agency Foundation of China (No. 07020304102). We thank all the people who helped us in our study, especially Domenico Lio and Nayoung Kim, who sent us their original paper.

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The authors declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, No. 218, Ji Xi Road, Hefei, 230022, China

    Feng Pan & Yue-Yin Pan

  2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81, Mei Shan Road, Hefei, 230032, China

    Jing Tian

  3. Department of Geriatrics, the Third Affiliated Hospital of Anhui Medical University, No. 390, Huai He Road, Hefei, 230061, China

    Ying Zhang

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Feng Pan and Jing Tian are contributed equally to this work and should be considered as co-first authors.

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Pan, F., Tian, J., Pan, YY. et al. Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case–control studies. Mol Biol Rep 39, 7143–7154 (2012). https://doi.org/10.1007/s11033-012-1546-7

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