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Vascular endothelial growth factor (VEGF) +405 C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran

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Abstract

Vascular endothelial growth factor (VEGF) has long been recognized as a hypotensive mediator. Little is known regarding the contribution of polymorphisms in VEGF gene to essential hypertension (EH), however. We aimed to investigate the association between +405 VEGF C/G single nucleotide polymorphism (SNP) and occurrence of EH in a sample of patients with diabetes. A study population of 474 subjects with diabetes of which 45.6% (216) had EH was enrolled in this study. Interviews and physical examinations were performed in a clinical setting. Subjects were matched in baseline anthropometric and biochemical characteristics except for total cholesterol. Genotyping of +405 VEGF C/G (rs2010963) SNP was carried out using polymerase chain reaction–restriction fragment length polymorphism. The allelic distribution of the sample did not violate Hardy–Weinberg equilibrium. Subjects with EH had a higher frequency of G allele (P = 0.005). Additionally, those with EH had a significantly higher frequency of GG genotype (P = 0.015). In multivariate logistic regression models controlling for possible confounders, having GG against CC genotype was associated with an odds ratio of 2.51 (95% CI: 1.44–4.38; P = 0.001). Moreover, presence of each G allele was linked to a 1.58-fold increase in risk of having EH (95% CI: 1.200–2.086; P = 0.001). In conclusion, +405 VEGF C/G SNP is associated with EH in patients with diabetes, suggesting presence of G allele and GG or CG genotype confer susceptibility towards EH.

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Acknowledgments

We wish to thank all medical and nursing team of Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital for collaboration in this project.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Health Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Amir Abbas Hamedian

  2. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Alireza Esteghamati, Sina Noshad, Mohammad Mozafari, Hosein Moin-Tavakkoli, Manouchehr Nakhjavani, Reza Safary & Abdolrahim Nikzamir

  3. Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Touraj Mahmoudi

  4. Farzanegan 2 High School, National Organization for Development of Exceptional Talents, Tehran, Iran

    Mahfam Nikzamir

  5. Department of Biochemistry, Faculty of Medicine, Ahvaz Jondi Shapour University of Medical Sciences, Ahvaz, Iran

    Abdolrahim Nikzamir

Authors
  1. Amir Abbas Hamedian
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  2. Alireza Esteghamati
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  3. Sina Noshad
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  4. Mohammad Mozafari
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  5. Hosein Moin-Tavakkoli
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  6. Manouchehr Nakhjavani
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  7. Touraj Mahmoudi
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  8. Mahfam Nikzamir
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  9. Reza Safary
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  10. Abdolrahim Nikzamir
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Correspondence to Abdolrahim Nikzamir.

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Hamedian, A.A., Esteghamati, A., Noshad, S. et al. Vascular endothelial growth factor (VEGF) +405 C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran. Mol Biol Rep 39, 6213–6218 (2012). https://doi.org/10.1007/s11033-011-1440-8

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  • DOI: https://doi.org/10.1007/s11033-011-1440-8

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