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Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?

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Abstract

This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls (P < 0.001). GlySer frequency is higher in diabetics than controls and non-diabetics (P < 0.001). Ser allele frequency is respectively increased in the order of diabetics > Controls > non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics.

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Acknowledgment

This present work was supported by the Research Fund of Istanbul University, project number: T-967/06102006.

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Authors and Affiliations

  1. Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Vakif Gureba Street, Capa-Istanbul, Turkey

    Ozlem Kucukhuseyin & Hulya Yilmaz-Aydogan

  2. Department of Cardiovascular Surgery, Marmara University School of Medicine, Istanbul, Turkey

    C. Selim Isbir

  3. Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey

    Turgay Isbir

Authors
  1. Ozlem Kucukhuseyin
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  2. Hulya Yilmaz-Aydogan
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  3. C. Selim Isbir
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  4. Turgay Isbir
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Correspondence to Ozlem Kucukhuseyin.

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Kucukhuseyin, O., Yilmaz-Aydogan, H., Isbir, C.S. et al. Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?. Mol Biol Rep 39, 4423–4428 (2012). https://doi.org/10.1007/s11033-011-1230-3

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  • DOI: https://doi.org/10.1007/s11033-011-1230-3

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