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Association between HFE polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis of 22 studies including 4,365 cases and 8,652 controls

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Abstract

Whether the variations in the hemochromatosis (HFE) gene increase Alzheimer’s disease (AD) risk is still undetermined. We performed a meta-analysis in order to systematically summarize the possible association. Studies were identified by searching PUBMED, Web of Science and EMBASE databases complemented with screening the references of the retrieved studies. The association was measured using random-effect or fixed-effect odds ratio (OR) combined with 95% confidence intervals (CIs) according to the studies’ heterogeneity. For C282Y polymorphism, we did not find any association using data from 22 studies including 4,365 cases and 8,652 controls. For H63D polymorphism, on the basis of 2,795 cases and 7,424 controls from 17 studies, we observed a significant association (allele contrast: OR = 0.902, 95% CI = 0.819–0.994, P = 0.037; minor-allele-dominant model: OR = 0.887, 95% CI = 0.790–0.996, P = 0.043). No publication bias was detected in this meta-analysis. The synthesis of available evidence supports mutant of HFE H63D polymorphism plays a protective role for AD risk.

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Acknowledgments

We thank Dr Kauwe from Department of Biology, Brigham Young University, for providing us the detailed information about their study; Dr Lehmann from Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, Oxford, UK, and Dr Ibrahim from Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands, for interpreting the overlapping dada via e-mail during the manuscript writing.

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Authors and Affiliations

  1. Department of Neurology, Fuzhou General Hospital, No.156 Xi’erhuan North Road, Fuzhou, 350025, China

    Min Lin, Lin Zhao, Jian-xin Ye, Lei Wu & Hang Lin

  2. Department of Neurology, Chengdu Military General Hospital, Chengdu, 610083, China

    Jin Fan

  3. Department of Neurology, Jinling Hospital, Nanjing, 210002, China

    Xue-Gan Lian

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  1. Min Lin
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  2. Lin Zhao
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  7. Hang Lin
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Correspondence to Min Lin or Hang Lin.

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Min Lin and Lin Zhao contributed equally to this article.

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Lin, M., Zhao, L., Fan, J. et al. Association between HFE polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis of 22 studies including 4,365 cases and 8,652 controls. Mol Biol Rep 39, 3089–3095 (2012). https://doi.org/10.1007/s11033-011-1072-z

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