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Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population

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Abstract

Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356, P = 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09, P = 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66, P < 0.0001 and OR 0.36, CI 0.24–0.55, P < 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors, i.e., CCR5 and CX3CR1.

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Acknowledgments

I would like to thank Dr. Nakul Sinha and Dr. Sudeep kumar for providing all clinical data. I would also like to thanks Dr. Suraksha Agrawal for supervising me in study design and manuscript writing. I am also thankful to Dr. C. M. Pandey for all his help in statistical analysis. All authors have read and approved the final manuscript.

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Authors and Affiliations

  1. Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India

    Neha Singh, Sudeep Kumar & Suraksha Agrawal

  2. Sahra Hospital, Lucknow, 226010, Uttar Pradesh, India

    Nakul Sinha

  3. Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India

    Chandra M. Pandey

  4. Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India

    Suraksha Agrawal

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  1. Neha Singh
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  2. Nakul Sinha
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  3. Sudeep Kumar
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  4. Chandra M. Pandey
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  5. Suraksha Agrawal
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Correspondence to Suraksha Agrawal.

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Singh, N., Sinha, N., Kumar, S. et al. Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population. Mol Biol Rep 39, 2753–2759 (2012). https://doi.org/10.1007/s11033-011-1031-8

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  • DOI: https://doi.org/10.1007/s11033-011-1031-8

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