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The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis

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Abstract

Epidemiological studies found inconsistent results on the association of two variants on TGFBR1 (TGFBR1*6A and Int7G24A) with colorectal cancer (CRC) risk. The present study was aimed to evaluate the association of these two variants with CRC susceptibility via the meta-analysis methods. For variant TGFBR1*6A, nine reports including 6,765 CRC patients and 8,496 unrelated controls were identified. The heterozygotes *6A/*9A showed a significant increased risk of CRC with the pooled OR was 1.12 (95% CI = 1.02–1.23), and the pooled OR for the homozygotes *6A/*6A was 1.13 (95% CI = 0.80–1.58) compared to the homozygotes *9A/*9A. However, under the dominant effect model, the TGFBR1*6A carriers showed a significantly increased CRC risk (pooled OR = 1.12, 95% CI = 1.03–1.23, *6A/*6A and *6A/*9A vs. *9A/*9A). For variant Int7G24A, three case–control studies with 1,074 cases and 1,945 controls were found. Although no significant association was found for heterozygosity Int7G24A carriers with CRC risk (pooled OR = 0.97, 95% CI = 0.67–1.42), the homozygosity A/A carriers showed a significant elevated risk of CRC (pooled OR = 1.68, 95% CI = 1.14–2.47) compared to G/G homozygotes. Under the recessive effect model, homozygotes A/A showed a 71% increase of CRC risk compared to the A/G and G/G genotype carriers (pooled OR = 1.71, 95% CI = 1.17–2.51). These data strongly suggested that the two polymorphisms of TGFBR1 may confer low-penetrance susceptibility of CRC risk.

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Abbreviations

CRC:

Colorectal cancer

TGFBR1/2:

Transforming growth factor, beta receptor I/II

OR:

Odds ratio

95% CI:

95% Confidential intervals

HWE:

Hardy–Weinberg equilibrium

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Authors and Affiliations

  1. Department of General Surgery, Central Hospital of Fengxian District, 9588 Nan Feng Road, Shanghai, 201400, People’s Republic of China

    Xueli Zhang, Youhua Sheng, Wenhua Zhou, Zhongming Huang, Jun Qu, Ganglong Gao & Ming Zhang

  2. Department of General Surgery, Huashan Hospital, Affiliated to FuDan University, Shanghai, People’s Republic of China

    Liang Wu & Duan Cai

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  1. Xueli Zhang
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  2. Liang Wu
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  4. Wenhua Zhou
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Correspondence to Xueli Zhang or Ming Zhang.

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Zhang, X., Wu, L., Sheng, Y. et al. The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis. Mol Biol Rep 39, 2567–2574 (2012). https://doi.org/10.1007/s11033-011-1009-6

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  • DOI: https://doi.org/10.1007/s11033-011-1009-6

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