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Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke

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Abstract

The 4G/5G polymorphism in the plasminogen activator inhibitor-1 (PAI-1) gene, has been associated with arterial disease. In this study, we investigated the association of IS in young patients with CRP and PAI-1 levels and frequency of insertion-deletion polymorphism of PAI-1 gene. The plasma levels of PAI-1 and CRP and the frequency of 4G/5G polymorphism were analyzed in 127 Brazilian young patients that presented IS and in 201 healthy and unrelated control subjects. The levels of CRP (P < 0.001) and PAI-1 (P < 0.001) were significantly higher in patients when compared with control group. Only PAI-1 plasma levels were independently associated with risk of IS (OR 3.40; 95% CI 1.49–7.74; P = 0.001) after adjustments for lifestyles covariates. The 4G/4G genotype was significantly more frequent among control subjects as compared to patients (OR 0.41; 95% CI 0.24–0.68; P < 0.001). Although increased PAI-1 plasma levels are associated with development of IS in Brazilian young patients, they are not influenced by the 4G/5G PAI-1 polymorphism.

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Acknowledgments

Authors are grateful to CNPq, FAPEMIG and CAPES for sponsoring this investigation.

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Authors and Affiliations

  1. Health Sciences Center, Federal University of São João Del Rei, Av. Sebastião Gonçalves Coelho, 400, Divinópolis, MG, CEP 35501 296, Brazil

    Adriano de Paula Sabino

  2. Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Adriano de Paula Sabino, Caroline Pereira Domingueti, Mariana Silva dos Santos, Luci Maria SantAna Dusse, Maria das Graças Carvalho & Ana Paula Fernandes

  3. University Hospital, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Daniel Dias Ribeiro

  4. Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    Telma Gadelha

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  1. Adriano de Paula Sabino
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  7. Maria das Graças Carvalho
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Correspondence to Adriano de Paula Sabino.

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de Paula Sabino, A., Ribeiro, D.D., Domingueti, C.P. et al. Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke. Mol Biol Rep 38, 5355–5360 (2011). https://doi.org/10.1007/s11033-011-0687-4

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  • DOI: https://doi.org/10.1007/s11033-011-0687-4

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