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Interferon gamma +874 T/A polymorphism contributes to cancer susceptibility: a meta-analysis based on 17 case–control studies

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Abstract

Interferon gamma (IFN-γ) plays a pivotal role in antiproliferative, antitumor and antiviral activities. The +874 polymorphism in IFN gene region reportedly affects cancer risk. However, pertinent studies offer conflicting results. To derive a more precise estimation, we performed a meta-analysis based on 1,929 cases and 2,830 controls from 17 published case–control studies, assessing the strength of the association using odds ratios with 95% confidence intervals. Our meta-analysis showed the evidence that IFN-γ +874 T/A was not associated with increased cancer risk in ethnicity and source of controls. However, stratified analysis by cancer type indicated a significantly increased risk of cervical cancer (AT vs. TT: OR = 1.10, 95% CI = 1.02–1.19, P = 0.961 for heterogeneity). Further prospective researches with a larger single study are required to evaluate any association with other types of cancer or in other populations.

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Authors and Affiliations

  1. Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China

    Yuan-Yuan Mi, Bin Xu, Li-Feng Zhang, Zhi-Chao Min, Li-Xin Hua & Ning-Han Feng

  2. Department of Ophthalmology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, China

    Qian-Qian Yu & Yong Yao

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  1. Yuan-Yuan Mi
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  2. Qian-Qian Yu
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  3. Bin Xu
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  4. Li-Feng Zhang
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Correspondence to Ning-Han Feng or Yong Yao.

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Yuan-Yuan Mi, Qian-Qian Yu and Bin Xu have contributed equally to this work.

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Mi, YY., Yu, QQ., Xu, B. et al. Interferon gamma +874 T/A polymorphism contributes to cancer susceptibility: a meta-analysis based on 17 case–control studies. Mol Biol Rep 38, 4461–4467 (2011). https://doi.org/10.1007/s11033-010-0575-3

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  • DOI: https://doi.org/10.1007/s11033-010-0575-3

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