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The role of actin and myosin during spermatogenesis

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Abstract

Spermatogenesis is a transitionary process in which the diploid spermatogonia transform into haploid mature spermatozoa. Actin and myosin have been implicated in various aspects during spermatogenesis. Actin is present in the form of monomer, oligomer and polymer within cells, the latter is called microfilament. There are five actin-containing structures during spermatogenesis, i.e., ectoplasmic specialization, acroplaxome, manchette in mammals, actin cones in Drosophila and acroframosome in Caridean shrimp. They are involved in the shaping and differentiating of spermatids. Along with spermatogenesis, the actin cytoskeletons show active remodeling in this process. Some actin binding or actin regulated proteins have been demonstrated to regulate dynamic changes of the actin-containing structures. Myosin, actin-dependent molecular motor, plays an important role during spermatogenesis, such as involving in acrosome biogenesis, vesicle transport, gene transcription and nuclear shaping. The actin cytoskeleton and actin binding/regulated proteins cooperate to facilitate spermatogenesis. In this review, we summarize the existing knowledge about the cytoskeletal structures consisting of actin, actin binding/regulated proteins and myosin during spermatogenesis.

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Acknowledgment

Grant sponsor National Natural Science Foundation of China, Grant No. 31072198 and 40776079; National Basic Research Program of China (973 Program), Grant No. 2007CB948104.

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Authors and Affiliations

  1. The Sperm Laboratory, Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, 388 Yu Hang Tang Road, Hangzhou, 310058, People’s Republic of China

    Xiao Sun & Wan-Xi Yang

  2. Department of Obstetrics and Gynaecology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary

    Tamas Kovacs

  3. Department of Reproductive Endocrinology, School of Medicine, Women’s Hospital, Zhejiang University, Hangzhou, 310006, People’s Republic of China

    Yan-Jun Hu

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  1. Xiao Sun
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  2. Tamas Kovacs
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  3. Yan-Jun Hu
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  4. Wan-Xi Yang
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Correspondence to Wan-Xi Yang.

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Xiao Sun and Tamas Kovacs contributed equally to this work.

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Sun, X., Kovacs, T., Hu, YJ. et al. The role of actin and myosin during spermatogenesis. Mol Biol Rep 38, 3993–4001 (2011). https://doi.org/10.1007/s11033-010-0517-0

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