Abstract
MicroRNAs (miRNAs) are a kind of endogenous non-coding small RNAs whose specific functions in animals are generally important. Although functions of some miRNAs have been identified, the role of miR-184 remains unknown. Here, we determined the temporal and spatial expression pattern of miR-184 during the different development stages and tissues in Drosophila. Strikingly, miR-184 is expressed ubiquitously in Drosophila embryos, larvae and adults, its expression pattern shows a dynamic changes during the development of embryo, especially in the central nervous system. This expression profile suggests that miR-184 may act important function in Drosophila development.
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References
Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294:853–858
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q. MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation. Mol Biol Rep 2009 Oct 10 [Epub ahead of print]
Huang Y, Zou Q, Tang SM, Wang LG, Shen XJ. Characterization of microRNAs from sheep (Ovis aries) using computational and experimental analyses. Mol Biol Rep 2010 Feb 7 [Epub ahead of print]
Kwon C, Han Z, Olson EN, Srivastava D (2005) MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci USA 102:18986–18991
Li Y, Wang F, Lee J-A, Gao F-B (2006) MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev 20:2793–2805
Teleman AA, Maitra S, Cohen SM (2006) Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev 20:417–422
Aboobaker AA, Tomancak P, Patel N, Rubin GM, Lai EC (2005) Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. PNAS 102(50):18017–18022
Wienholds E, Kloosterman WP, Miska E et al (2005) MicroRNA expression in zebrafish embryonic development. Science 309(5732):310–311
Nomura T, Kimura M, Horii T et al (2008) MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum Mol Genet 17(8):1192–1199
Chen YX, Stallings RL (2007) Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis. Cancer Res 67(3):976–983
Iovino N, Pane A, Gaul U (2009) miR-184 has multiple roles in Drosophila female germline development. Dev Cell 17:123–133
Aravin AA, Lagos-Quintana M, Yalcin A et al (2003) The small RNA profile during Drosophila melanogaster development. Dev Cell 5:337–350
Acknowledgements
We thank the Bloomington stocks center for fly stocks, this work was supported by NSFC (30670444).
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Li, P., Peng, J., Hu, J. et al. Localized expression pattern of miR-184 in Drosophila . Mol Biol Rep 38, 355–358 (2011). https://doi.org/10.1007/s11033-010-0115-1
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DOI: https://doi.org/10.1007/s11033-010-0115-1