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Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats

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Abstract

Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) “Li-Yan Zhi-Ke Granule” in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM “Li-Yan Zhi-Ke Granule” may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.

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Authors and Affiliations

  1. Chengdu Medical College, Chengdu, 610083, Sichuan Province, China

    Yiyi Sun, Zhihe Zang, Xiaohong Xu, Zhonglin Zhang, Ling Zhong, Wang Zan & Yan Zhao

  2. West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China

    Lin Sun

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  1. Yiyi Sun
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  2. Zhihe Zang
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  3. Xiaohong Xu
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  4. Zhonglin Zhang
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  5. Ling Zhong
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  6. Wang Zan
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  7. Yan Zhao
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  8. Lin Sun
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Correspondence to Lin Sun.

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Sun, Y., Zang, Z., Xu, X. et al. Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats. Mol Biol Rep 38, 199–203 (2011). https://doi.org/10.1007/s11033-010-0095-1

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  • DOI: https://doi.org/10.1007/s11033-010-0095-1

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