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Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays

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Abstract

We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.

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Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (No 30801255), the Natural Science Foundation of Jiangsu Province, China (BK2006009).

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Authors and Affiliations

  1. Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004, Nanjing, China

    Jie Qiu, Qin Hong, Mei-ling Tong, Min Zhang, Xi-rong Guo & Xia Chi

  2. Institute of Pediatrics of Nanjing Medical University, 210029, Nanjing, China

    Rong-hua Chen, Mei-ling Tong, Min Zhang, Li Fei, Xiao-qin Pan, Mei Guo, Xi-rong Guo & Xia Chi

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  1. Jie Qiu
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  2. Qin Hong
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  3. Rong-hua Chen
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Correspondence to Xi-rong Guo or Xia Chi.

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The authors Jie Qiu and Qin Hong contributed equally to this work.

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Qiu, J., Hong, Q., Chen, Rh. et al. Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays. Mol Biol Rep 37, 1733–1740 (2010). https://doi.org/10.1007/s11033-009-9596-1

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