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The human leukocyte antigen class I genes in nasopharyngeal carcinoma risk

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Abstract

Nasopharyngeal carcinoma (NPC) is a virally associated cancer which is highly prevalent in Southeast Asia and North Africa. Several linkage analysis studies suggested the association of susceptibility HLA (Human Leukocyte Antigen) alleles and haplotypes with NPC development. The HLA system is very polymorphic and according to the ethnic group studied, it has been found to have the capacity to confer susceptibility or resistance to NPC. Our aim was to review the most important described genetic associations of HLA class I in NPC and to comment on the inconsistent associations found in the different NPC incidence areas. We believe that the mechanisms of these associations may involve HLA genes through the differential capacity of each allele to present antigens. However, because HLA genes contain various linked candidate genes, HLA-NPC associations should be carefully interpreted.

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Acknowledgments

We would like to thank Mr Adel Rdissi for English revision.

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Authors and Affiliations

  1. Faculty of Medicine of Monastir, Molecular Immuno-oncology Laboratory, Monastir University, 5019, Monastir, Tunisia

    Elham Hassen, Ghandri Nahla, Noureddine Bouaouina & Lotfi Chouchane

  2. Departement of Cancerology and Radiotherapy, CHU Farhat Hached, Sousse, Tunisia

    Noureddine Bouaouina

  3. Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar

    Lotfi Chouchane

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  1. Elham Hassen
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  2. Ghandri Nahla
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  3. Noureddine Bouaouina
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  4. Lotfi Chouchane
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Correspondence to Elham Hassen.

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The authors E. Hassen and G. Nahla contributed equally to this review.

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Hassen, E., Nahla, G., Bouaouina, N. et al. The human leukocyte antigen class I genes in nasopharyngeal carcinoma risk. Mol Biol Rep 37, 119–126 (2010). https://doi.org/10.1007/s11033-009-9548-9

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