Skip to main content
SpringerLink
Log in

Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Allergic Rhinitis (AR) and allergic asthma (AS) are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of ‘one airway, one disease’. A disintegrin and metalloproteinase 33 (ADAM33) was discovered as the first asthma-susceptible gene by positional cloning. To evaluate the potential influences of ADAM33 gene polymorphisms on concomitant allergic rhinitis and asthma (ARA), a case-control study was conducted in Han population of Northeast China. Six polymorphic sites (V4, T + 1, T2, T1, S1 and Q − 1) were genotyped in 135 ARA patients and 151 controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data was analyzed using the Chisquaretest and Haploview software. The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q − 1A/G) of the ADAM33 gene may be the causal variants in ARA disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Management of allergic rhinitis and its impact on asthma: pocket guide (2001) Asthma workshop report in collaboration with the World Health Organization. WHO, Geneva

  2. Asthma management handbook (2002) National Asthma Council Australia Ltd, Melbourne

  3. Corren J, Togias A, Bousquet J (2003) Upper and lower respiratory disease. In: Lung biology in health and disease, vol 181. Marcel Dekker, New York

  4. Togias A (2003) Rhinitis and asthma: evidence for respiratory system integration. J Allergy Clin Immunol 111:1171–1183. doi:10.1067/mai.2003.1592

    Article  PubMed  Google Scholar 

  5. Gaga M, Lambrou P, Papageorgiou N et al (2000) Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis. Clin Exp Allergy 30:663–669. doi:10.1046/j.1365-2222.2000.00804.x

    Article  PubMed  CAS  Google Scholar 

  6. Van Eerdewegh P, Little RD, Dupuis J et al (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418:426–430. doi:10.1038/nature00878

    Article  PubMed  Google Scholar 

  7. Postma DS, Howard T (2004) ADAM33 gene: confirming a gene without linkage. Clin Exp Allergy 34:1–3. doi:10.1111/j.1365-2222.2004.01845.x

    Article  PubMed  CAS  Google Scholar 

  8. Howard TD, Postma DS, Jongepier H et al (2003) Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 112:717–722. doi:10.1016/S0091-6749(03)01939-0

    Article  PubMed  CAS  Google Scholar 

  9. Cheng L, Enomoto T, Hirota T et al (2004) Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. Clin Exp Allergy 34:1192–1201. doi:10.1111/j.1365-2222.2004.02008.x

    Article  PubMed  CAS  Google Scholar 

  10. Lee JH, Park HS, Park SW et al (2004) ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy 34:860–865. doi:10.1111/j.1365-2222.2004.01977.x

    Article  PubMed  CAS  Google Scholar 

  11. Noguchi E, Ohtsuki Y, Tokunaga K et al (2006) ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin Exp Allergy 36:602–608. doi:10.1111/j.1365-2222.2006.02471.x

    Article  PubMed  CAS  Google Scholar 

  12. Sakagami T, Jinnai N, Nakajima T et al (2007) ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet 52:66–72. doi:10.1007/s10038-006-0081-6

    Article  PubMed  CAS  Google Scholar 

  13. Hirota T, Hasegawa K, Obara K et al (2006) Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy 36:884–891. doi:10.1111/j.1365-2222.2006.02522.x

    Article  PubMed  CAS  Google Scholar 

  14. Lind DL, Choudhry S, Ung N et al (2003) ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med 168:1312–1316. doi:10.1164/rccm.200306-877OC

    Article  PubMed  Google Scholar 

  15. Raby BA, Silverman EK, Kwiatkowski DJ et al (2004) ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol 113:1071–1078. doi:10.1016/j.jaci.2004.03.035

    Article  PubMed  CAS  Google Scholar 

  16. Werner M, Herbon N, Gohlke H et al (2004) Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy 34:26–31. doi:10.1111/j.1365-2222.2004.01846.x

    Article  PubMed  CAS  Google Scholar 

  17. Comorbid Asthma and Allergic Rhinitis One Airway, One Disease (2007) European Respiratory Society Annual Congress, Stockholm, Sweden

  18. Rha Y-H, Sohn B-K (2007) Evaluation and control of allergic rhinitis in patients with asthma in Korea. Eur Respir J 30(Suppl 51):383

    Google Scholar 

  19. Stojanovska V, Zafirovski O, Petrusevska (2007) Allergic rhinitis in asthmatic children. Eur Respir J 30(Suppl 51):383

Download references

Acknowledgements

This work was supported by the Project of Science Research Foundation of Heilongjiang (Grant No. 11531145) and a grant from the Innovative Fund of Harbin Medical University Graduate Student (HCXB2007004). We thank all patients and healthy blood donors for providing blood samples. We are grateful for the collaboration received from the participating hospitals and their staff.

Author information

Authors and Affiliations

  1. Department of Histology and Embryology, Harbin Medical University, Harbin, 150086, China

    Ximei Zhang & Lianhong Jin

  2. Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China

    Dongju Su, Fuzhen Lü & Jing Zhang

  3. Department of Genetics, Harbin Medical University, Harbin, 150086, China

    Xuelong Zhang

  4. Department of Statistics, Harbin Medical University, Harbin, 150086, China

    Hong Sui

Authors
  1. Ximei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dongju Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuelong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hong Sui
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lianhong Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fuzhen Lü
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jing Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Lianhong Jin or Fuzhen Lü.

Additional information

Ximei Zhang and Dongju Su contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, X., Su, D., Zhang, X. et al. Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population. Mol Biol Rep 36, 1505–1509 (2009). https://doi.org/10.1007/s11033-008-9343-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-008-9343-z

Keywords

Search

Navigation