Abstract
Inositol polyphosphate-5-phosphatase F (INPP5F) is one of the largest families of phosphoinositide phosphatases, 5-phosphatase. It contains a Sac domain whose amino acids are essential for inositol polyphosphate phosphatase activities. Here, we assigned the porcine INPP5F to SSC14q29 by using SCHP and IMpRH. Sequencing of PCR products from different breeds identified an A/G polymorphism in the last exon. The allele frequencies of this SNP showed that the Yorkshire and Duroc pigs have high G allele frequency, whereas the local pigs have high A allele frequency. Association analysis of the genotypes with growth and carcass traits found that different genotypes of INPP5F have significant differences in average daily gain (ADG) (P < 0.05) in Yorkshire pigs.
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Acknowledgements
We thank Dr. Martine Yerle in INRA, France, for providing the RH panel. We thank Fang Mingdi for help with data analysis. The research was supported by Key Project of National Basic Research and Developmental Plan (2006CB102105) of China, National Natural Science Foundation of China (30571328), and National High Science and Technology Foundation of China “863” (2006AA10Z195).
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Zhou, QY., Huang, JN., Zhu, MJ. et al. Molecular characterization and association analysis with production traits of the porcine INPP5F Gene. Mol Biol Rep 36, 1095–1098 (2009). https://doi.org/10.1007/s11033-008-9283-7
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DOI: https://doi.org/10.1007/s11033-008-9283-7