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ACE gene polymorphism and cardiac structure in patients with insulin resistance

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Abstract

Aims: Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II, thus may participate in the modulation of cardiac growth. The aim of our study is to analyze the ACE gene I/D polymorphisms in patients with insulin resistance (IR) and to evaluate its relationship to left ventricular mass and functions. Methods: Eighteen subjects (13 female and 5 male, mean age 39.8 ± 14) with IR were enrolled in the present study. Twenty-three healthy people without IR were recruited as the control group. ACE amplification of DNA was performed by polymerase chain reaction methodology. Fasting glucose and insulin, postprandial glucose, homeostasis model assessment (HOMA-IR) and HOMA-beta, lipid profile, anthropometric measurements were assessed. Left ventricular structure and functions were measured by echocardiography. Results: Distribution of I/D polymorphism of the ACE gene in the study group was as follows: genotype II–0%, ID–38.9%, DD–61.1% of patients. Distribution of individual genotypes was similar in patients with and without IR. No significant difference was found between genotype groups in terms of anthropometric measurements and metabolic parameters and blood pressure. Echocardiography showed no significant changes in left ventricular structure and functions in patients with IR. Conclusions: We considered that in patients with IR, there is no relationship between I/D polymorphism of the ACE gene and LVH.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Endocrinology and Metabolism, Pamukkale University, Kinikli Campus, 20070, Denizli, Turkey

    Fulya Akin

  2. Faculty of Medicine, Department of Physiology, Pamukkale University, Denizli, Turkey

    Sebahat Turgut & Gunfer Turgut

  3. Faculty of Medicine, Department of Cardiology, Pamukkale University, Denizli, Turkey

    Dursun Dursunoglu & Sukru Gur

  4. Faculty of Medicine, Department of Internal Medicine, Pamukkale University, Denizli, Turkey

    Ugur Karasu

Authors
  1. Fulya Akin
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  2. Sebahat Turgut
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  3. Dursun Dursunoglu
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  4. Gunfer Turgut
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  5. Ugur Karasu
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  6. Sukru Gur
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Correspondence to Fulya Akin.

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Akin, F., Turgut, S., Dursunoglu, D. et al. ACE gene polymorphism and cardiac structure in patients with insulin resistance . Mol Biol Rep 36, 623–629 (2009). https://doi.org/10.1007/s11033-008-9222-7

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  • DOI: https://doi.org/10.1007/s11033-008-9222-7

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