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The JMJD2 members of histone demethylase revisited

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Abstract

The study of histone lysine demethylases has become very hot recently. Many histone demethylases have been reported by different research groups with various techniques. However, how many histone lysine-methylation states can be removed by one specific demethylase and how many demethylases can remove one specific histone lysine-methylation state? It remains a daunting challenge to answer these questions to date. An in-depth discussion on recent results, three important points were provided: (1) Some demethylases can remove more histone lysine-methylation states; (2) Some prokaryotes might be endowed with histone lysine demethylases although they are devoid of histones; (3) Protein-protein interaction provides a valuable framework for a better understanding of the functions of the histone lysine demethylases. All of these will be beneficial to a better understanding of demethylases and suggest how future research can be improved.

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Acknowledgements

This work was supported by CAS “100 Talents” program. The authors also thank the anonymous reviewers for a number of suggestions that have improved the quality of the paper.

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  1. Division of Biotechnology, Dalian Institute of Chemical Physics, CAS, 457 Zhongshan Road, Dalian, 116023, P.R. China

    Haidong Tan, Siguo Wu, Jinxia Wang & Zongbao (Kent) Zhao

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  1. Haidong Tan
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  2. Siguo Wu
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  3. Jinxia Wang
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Correspondence to Haidong Tan.

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Tan, H., Wu, S., Wang, J. et al. The JMJD2 members of histone demethylase revisited. Mol Biol Rep 35, 551–556 (2008). https://doi.org/10.1007/s11033-007-9121-3

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  • DOI: https://doi.org/10.1007/s11033-007-9121-3

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