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Lupenone is a good anti-inflammatory compound based on the network pharmacology

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Abstract

The dried rhizome of Musa basjoo Sieb. et Zucc. is Rhizoma Musae. It has been used to treat diabetes in Miao medicine in China. Lupenone was isolated from Rhizoma Musae and has good anti-diabetic activity. Its mechanism of action is unclear. Diabetes is a chronic low-level systemic inflammatory disease, and lupenone has anti-inflammatory activity, but the underlying mechanism is not fully elucidated. In this study, we aimed to construct the drug-target biologic network and predict the anti-inflammatory mechanism of lupenone. The network-based pharmacologic analysis platform was used to identify the target proteins related to inflammation. Furthermore, the effects of lupenone on acute, subacute and diabetic pancreatic inflammation were evaluated. The “component-target-disease” network was constructed using Cytoscape. Lupenone could regulate transcription factor p65, NF-kappa-B inhibitor alpha, transcription factor AP-1, NF-kappa-B essential modulator, nuclear factor NF-kappa-B p105 subunit, epidermal growth factor receptor, hypoxia-inducible factor 1-alpha and other proteins related to the PI3K-Akt, Toll-like receptor and NF-kappa B signaling pathways. In addition, lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1β and IFN-γ levels in the pancreas of diabetic rats. The above results provide strong support for studying the molecular mechanism of lupenone in the treatment of diabetes from the perspective of anti-inflammation.

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Acknowledgements

This work was supported by Guiyang University of Chinese Medicine Doctor Startup Fund (2017), NSFC (81860737), The Guizhou domestic first-class construction project [(Chinese Materia Medica) (GNYL [2017] 008)] and Guizhou Province Science and Technology Project (QiankeheLHzi [2016] 7116).

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Authors and Affiliations

  1. College of Pharmacy, Guiyang University of Chinese Medicine, Guiyang, People’s Republic of China

    Feng Xu, Liubo Yang, Xulong Huang, Yuqing Liang & Xiangpei Wang

  2. Experiment Center, Guiyang University of Chinese Medicine, 50, Nanming District, Guiyang, 550002, Guizhou Province, People’s Republic of China

    Hongmei Wu

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Correspondence to Hongmei Wu.

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Xu, F., Yang, L., Huang, X. et al. Lupenone is a good anti-inflammatory compound based on the network pharmacology. Mol Divers 24, 21–30 (2020). https://doi.org/10.1007/s11030-019-09928-5

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