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Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives “on water”

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Abstract

This research describes a simple and efficient one-pot synthetic approach for the preparation of tetrahydrodiazepine and dihydropyrazine (or dihydroquinoxaline) derivatives in high yields in the presence of a substoichiometric amount of ammonium chloride as a green accelerator on water at 50 °C within 1–3 h.

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Acknowledgements

We gratefully acknowledge financial support from the Iran National Science Foundation (INSF) and Research Council of Shahid Beheshti University.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716, Tehran, Iran

    Ahmad Shaabani, Heshmatollah Sepahvand & Shima Ghasemi

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  1. Ahmad Shaabani
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  2. Heshmatollah Sepahvand
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  3. Shima Ghasemi
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Correspondence to Ahmad Shaabani.

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Shaabani, A., Sepahvand, H. & Ghasemi, S. Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives “on water”. Mol Divers 23, 585–592 (2019). https://doi.org/10.1007/s11030-018-9893-5

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