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A general three-step one-pot synthesis of novel (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acids

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Abstract

In this work, a facile and general three-step one-pot synthesis of structurally new (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acid derivatives has been achieved from easily available ethyl 6-chloro-2-(chloromethyl) quinoline-3-carboxylate and aromatic or heteroaromatic aldehydes. This strategy features simple one-pot operation, tolerance of a wide range of substituents, and good yields. Moreover, these newly synthesized compounds belong to a new class of quinoline derivatives and could be good candidates for the development of more complex quinoline compounds for use in medicinal chemistry.

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Acknowledgements

The project was financially supported by the National Natural Science Foundation of China (No. 21402011).

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Authors and Affiliations

  1. College of Land and Environmental Science, Shenyang Agricultural University, Shenyang, 110866, People’s Republic of China

    Yang Li & Hongtao Zou

  2. Institute of Superfine Chemicals, Bohai University, Keji Street, Jinzhou, 121000, People’s Republic of China

    Yang Li & Yang Wang

Authors
  1. Yang Li
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  2. Yang Wang
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  3. Hongtao Zou
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Correspondence to Yang Li or Hongtao Zou.

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Li, Y., Wang, Y. & Zou, H. A general three-step one-pot synthesis of novel (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acids. Mol Divers 21, 463–473 (2017). https://doi.org/10.1007/s11030-017-9730-2

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  • DOI: https://doi.org/10.1007/s11030-017-9730-2

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