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Spiro[pyrrolidine-2,3′-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions

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Abstract

A series of spiro-oxindole derivatives was synthesized by novel regioselective 1,3-dipolar cycloadditions of isatin, α-amino acids, and (E)-β-aryl-nitro-olefins. Regioisomers were produced in each reaction and the major products showed different regioselectivity compared to previously reported spiro-oxindole derivatives.

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Authors and Affiliations

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China

    Gang Chen, Suo Gao, Hongping He, Shunlin Li, Yingtong Di & Xiaojiang Hao

  2. School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai, 200240, China

    Jing Yang

  3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China

    Ying Chang & Yang Lu

  4. College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi, 710065, China

    Gang Chen

Authors
  1. Gang Chen
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  2. Jing Yang
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  3. Suo Gao
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  4. Hongping He
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  5. Shunlin Li
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  6. Yingtong Di
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  7. Ying Chang
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  8. Yang Lu
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  9. Xiaojiang Hao
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Corresponding author

Correspondence to Gang Chen.

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Chen, G., Yang, J., Gao, S. et al. Spiro[pyrrolidine-2,3′-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions. Mol Divers 16, 151–156 (2012). https://doi.org/10.1007/s11030-011-9342-1

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  • DOI: https://doi.org/10.1007/s11030-011-9342-1

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