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A facile and one pot synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from terminal alkynes and phenacyl azides prepared from styrenes by CAN oxidant and sodium azide

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Abstract

A facile and green synthesis of 1,4-disubstituted-1H-1,2,3-triazoles is reported. The reaction of α-azido ketones and terminal alkynes in the presence of [CuSO4 (H2O)5/sodium ascorbate] in a mixture of H2O/polyethylene glycol 400 as solvent afforded the corresponding 1,4-disubstituted triazoles at ambient temperature with short reaction times and at high yields. The corresponding α-azido ketones were directly prepared in situ from various substituted styrenes using the oxidant cerium ammonium nitrate and sodium azide in oxygen-saturated methanol.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Shahid Chamran University, Ahvaz, 61357-4-3169, Iran

    Mosadegh Keshavarz & Rashid Badri

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  1. Mosadegh Keshavarz
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  2. Rashid Badri
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Correspondence to Rashid Badri.

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Keshavarz, M., Badri, R. A facile and one pot synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from terminal alkynes and phenacyl azides prepared from styrenes by CAN oxidant and sodium azide. Mol Divers 15, 957–962 (2011). https://doi.org/10.1007/s11030-011-9327-0

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  • DOI: https://doi.org/10.1007/s11030-011-9327-0

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