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Combinatorial chemistry: oh what a decade or two can do

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Abstract

This short commentary takes a stroll through the early days of the field of combinatorial chemistry and molecular diversity. It offers a high-level perspective on the field’s beginnings—and its future—as it relates to journals, books, pioneers, and advances.

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Abbreviations

ADME:

Absorption, distribution, metabolism, and excretion or elimination

DOS:

Diversity-oriented synthesis

%F:

Bioavailability

GPCR:

G-protein-coupled receptor

HTS:

High-throughput screening

MCR:

Multicomponent reaction

MW:

Molecular weight

NCE:

New chemical entity

PK:

Pharmacokinetics

NROT:

Number of rotatable bonds

SAR:

Structure–activity relationship

SBDD:

Structure-based drug design

SPOC:

Solid-phase organic chemistry

SPOS:

Solid-phase organic synthesis

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Authors and Affiliations

  1. SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, USA

    Walter H. Moos

  2. University of California, San Francisco, CA, USA

    Walter H. Moos

  3. Prosetta Bioconformatics, Inc., San Francisco, CA, USA

    Clarence R. Hurt

  4. Semafore Pharmaceuticals, Inc., Indianapolis, IN, USA

    Guillermo A. Morales

Authors
  1. Walter H. Moos
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  2. Clarence R. Hurt
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  3. Guillermo A. Morales
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Correspondence to Walter H. Moos.

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Moos, W.H., Hurt, C.R. & Morales, G.A. Combinatorial chemistry: oh what a decade or two can do. Mol Divers 13, 241–245 (2009). https://doi.org/10.1007/s11030-009-9127-y

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  • DOI: https://doi.org/10.1007/s11030-009-9127-y

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