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Brain proton magnetic spectroscopy in long-term treatment of Wilson’s disease patients

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Abstract

We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson’s disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated four hWD patients, with no improvement and eight with marked improvement; and eight nWD patients with marked improvement and seven with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.

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Acknowledgements

This work was supported by grant from the Polish Ministry of Education and Science (3P05B/119/23).

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Authors and Affiliations

  1. II Department of Neurology, Institute of Psychiatry and Neurology, 9 Sobieskiego Str., 02-957, Warsaw, Poland

    Beata Tarnacka & Anna Członkowska

  2. II Department of Clinical Radiology, Warsaw Medical University, Warsaw, Poland

    Wojciech Szeszkowski

  3. I Department of Clinical Radiology, Warsaw Medical University, Warsaw, Poland

    Marek Gołębiowski

  4. Department of Clinical and Experimental Pharmacology, Medical Academy, Warsaw, Poland

    Anna Członkowska

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  1. Beata Tarnacka
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  2. Wojciech Szeszkowski
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  3. Marek Gołębiowski
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  4. Anna Członkowska
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Correspondence to Beata Tarnacka.

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Tarnacka, B., Szeszkowski, W., Gołębiowski, M. et al. Brain proton magnetic spectroscopy in long-term treatment of Wilson’s disease patients. Metab Brain Dis 25, 325–329 (2010). https://doi.org/10.1007/s11011-010-9214-x

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  • DOI: https://doi.org/10.1007/s11011-010-9214-x

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