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Bio-ecological control of chronic liver disease and encephalopathy

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Abstract

Minimal encephalopathy was originally associated with chronic liver disease but is increasingly associated with most other chronic diseases and particularly with diabetes and also chronic disorders in other organs: kidneys, lungs, thyroid and with obesity. It is increasingly with dramatically increased and more or less permanent increase in systemic inflammation, most likely a result of Western lifestyle. Frequent physical exercise and intake of foods rich in vitamins, antioxidants, fibres, lactic acid bacteria etc in combination with reduction in intake of refined and processed foods is known to reduce systemic inflammation and prevent chronic diseases. Some lactic acid bacteria, especially Lb paracasei, lb plantarum and pediococcus pentosaceus have proven effective to reduce inflammation and eliminate encephalopathy. Significant reduction in blood ammonia levels and endotoxin levels were reported in parallel to improvement of liver disease. Subsequent studies with other lactic acid bacteria seem to demonstrate suppression of inflammation and in one study also evidence of clinical improvement.

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References

  • Ahrné S, Nobaek S, Jeppsson B, Adlerberth I, Wold AE, Molin G (1998) The normal Lactobacillus flora of healthy human rectal and oral mucosa. J Appl Microbiol 85(1):88–94, PMID: 9721659

    Article  PubMed  Google Scholar 

  • Almersjö O, Bengmark S, Hafström LO, Olsson R (1969) Enzyme and function changes after extensive liver resection in man. Ann Surg 169(1):111–119, PMID: 5762442

    Article  PubMed  Google Scholar 

  • Baptista JAB, Carvalho RCB (2004) Indirect determination of Amadori compounds in milk-based products by HPLC/ELSD/UV as an index of protein detorioration. Food Research International 37:739–747

    Article  CAS  Google Scholar 

  • Bengmark S (2001) Nutritional modulation of acute and “chronic” phase response. Nutrition 17:489–495, PMID: 11434344

    Article  PubMed  CAS  Google Scholar 

  • Bengmark S (2004) Acute and “chronic” phase response—a mother of disease. Clin Nutr 23:1256–1266, PMID: 15556248

    Article  PubMed  Google Scholar 

  • Bengmark S (2006) Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr 30(1):45–51, PMID: 16387899

    Article  PubMed  CAS  Google Scholar 

  • Bengmark S (2007) Advanced glycation and lipoxidation end products—amplifiers of inflammation: the role of food. JPEN J Parenter Enteral Nutr 31(5):430–440, PMID: 17712153

    Article  PubMed  CAS  Google Scholar 

  • Bengmark S (2008) Control of systemic inflammation and chronic diseases—the use of turmeric and curcuminoids. In: Mine, Miyashita, Shahidi (Ed) Nutrigenomics and proteogenomics in health and disease: Impact of food factors-gene interactions. Under publication

  • Bengmark S, Olsson R (1962a) Effect of vitamin B12 on liver regeneration after carbon tetrachloride injury. Lab Invest 11:235–239, PMID: 13867203

    PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1962b) The effect of sex and of testosterone on toxic liver damage. J Endocrinol 25:293–297, PMID: 13967433

    Article  PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1963a) Effect of vitamin B12 on liver regeneration after partial hepatectomy. Gastroenterologia 100:75–86, PMID: 14062564

    Article  PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1963b) Experimental study of liver healing after partial hepatectomy. Special regard to changes in content of liver glutamic pyruvic transaminase. Acta Hepatosplenol 10:283–293, PMID: 14089254

    PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1963c) Effect of testosterone upon liver regeneration. Bull Soc Int Chir 22:451–457, PMID: 14108493

    PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1964a) The effect of testosterone on liver healing after partial hepatectomy. Acta Chir Scand 127:93–100, PMID: 14104711

    PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R (1964b) The effect of castration and testosterone treatment on liver healing in male rats after carbon tetrachloride injury. Pathol Microbiol (Basel) 27:167–174, PMID: 14122870

    Article  CAS  Google Scholar 

  • Bengmark S, Ekdahl PH, Olsson R (1964a) Effect of taurine and glycine treatment on the conjugation of bile acids in partially hepatectomized rats. Acta Chir Scand 128:180–185, PMID: 14196495

    PubMed  CAS  Google Scholar 

  • Bengmark S, Olsson R, Svanborg A (1964b) Fat infiltration after partial hepatectomy. Changes in glycerides, cholesterol and phospholipids in the residual liver of the rat. Acta Hepatosplenol 11:276–285, PMID: 14325227

    PubMed  CAS  Google Scholar 

  • Bengmark S, Ekman B, Olsson R, Rehnström B (1966a) Further studies on the effect of testosterone on liver healing after partial hepatectomy in male rats. Scand J Gastroenterol 1(2):106–110, PMID: 5963565

    PubMed  CAS  Google Scholar 

  • Bengmark S, Edlund Y, Olsson R (1966b) Serum, liver and bile transaminases during extrahepatic biliary obstruction in the rat. Acta Hepatosplenol 13(2):84–88, PMID: 5992181

    PubMed  CAS  Google Scholar 

  • Bengmark S, Ekdahl PH, Gottfries A, Mobacken H, Olsson R, Rehnström B, Scherstén T (1966c) Influence of testosterone treatment in experimental nutritional hepatic cirrhosis in the rat. Gastroenterologia 105(5):301–315, PMID: 5958907

    Article  PubMed  CAS  Google Scholar 

  • Brandtzaeg P, Halstensen TS, Kett K, Krajci P, Kvale D, Rognum TO et al (1989) Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97(6):1562–1584, PMID: 2684725

    PubMed  CAS  Google Scholar 

  • Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi’ F et al (2008) Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res 11(2):425–432, PMID: 18442326

    Article  PubMed  CAS  Google Scholar 

  • Chen H, O’Reilly E, McCullough ML, Rodriguez C, Schwarzschild MA, Calle EE et al (2007) Consumption of dairy products and risk of Parkinson’s disease. Am J Epidemiol 165(9):998–1006, PMID: 17272289

    Article  PubMed  Google Scholar 

  • Debarry J, Garn H, Hanuszkiewicz A, Dickgreber N, Blümer N, von Mutius E et al (2007) Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties. J Allergy Clin Immunol 119(6):1514–1521, PMID: 17481709

    Article  PubMed  Google Scholar 

  • Eutamene H, Bueno L (2007) Role of probiotics in correcting abnormalities of colonic flora induced by stress. Gut 56(11):1495–1497, PMID: 17938427

    Article  PubMed  CAS  Google Scholar 

  • Eutamene H, Lamine F, Chabo C, Theodorou V, Rochat F, Bergonzelli GE (2007) Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats. J Nutr 137(8):1901–1907, PMID: 17634262

    PubMed  CAS  Google Scholar 

  • Finegold SM et al (1983) Human intestinal microflora in health and disease. Academic, London, pp 3–31

    Google Scholar 

  • Fujiwara D, Inoue S, Wakabayashi H, Fujii T (2004) The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Int Arch Allergy Immunol 135(3):205–215, PMID: 15467373

    Article  PubMed  CAS  Google Scholar 

  • Ganmaa D, Li XM, Wang J, Qin LQ, Wang PY, Sato A (2002) Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices. Int J Cancer 98(2):262–267 10, PMID: 11857417

    Article  PubMed  CAS  Google Scholar 

  • Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH (2007) Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut 56(11):1522–1528, PMID: 17339238 (Erratum in: Gut. 2008 Apr;57(4):560)

    Article  PubMed  CAS  Google Scholar 

  • Goldberg T, Cai W, Peppa M, Dardaine V, Baliga BS, Uribarri J et al (2004) Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 104(8):1287–91, PMID: 15281050

    Article  PubMed  CAS  Google Scholar 

  • Hein G, Franke S (2002) Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia? Rheumatology (Oxford) 41(10):1163–1167, PMID: 12364637

    Article  CAS  Google Scholar 

  • Holmes MD, Pollak MN, Willett WC, Hankinson SE (2002a) Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev 11(9):852–861, PMID: 12223429

    PubMed  CAS  Google Scholar 

  • Holmes MD, Pollak MN, Hankinson SE (2002b) Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev 11(9):862–867, PMID: 12223430

    PubMed  CAS  Google Scholar 

  • Hyogo H, Yamagishi S, Iwamoto K, Arihiro K, Takeuchi M, Sato T et al (2007) Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol 22(7):1112–1119, PMID: 17559366

    Article  PubMed  CAS  Google Scholar 

  • Ibnou-Zekri N, Blum S, Schiffrin EJ, von der Weid T (2003) Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro. Infect Immun 71(1):428–436, PMID: 12496193

    Article  PubMed  CAS  Google Scholar 

  • Jiang R, Camargo CA Jr, Varraso R, Paik DC, Willett WC, Barr RG (2008) Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr 87(4):1002–1008, PMID: 18400725

    PubMed  CAS  Google Scholar 

  • Kiraly MA, Kiraly SJ (2005) The effect of exercise on hippocampal integrity: review of recent research. Int J Psychiatry Med 35(1):75–89, PMID: 15977946

    Article  PubMed  Google Scholar 

  • Kohut ML, Senchina DS (2004) Reversing age-associated immunosenescence via exercise. Exerc Immunol Rev 10:6–41, PMID: 15633584

    PubMed  Google Scholar 

  • Kop WJ, Weissman NJ, Zhu J, Bonsall RW, Doyle M, Stretch MR, Glaes SB, Krantz DS, Gottdiener JS, Tracy RP (2008) Effects of acute mental stress and exercise on inflammatory markers in patients with coronary artery disease and healthy controls. Am J Cardiol 101:767–773, Mar 15, PMID: 18328837

    PubMed  Google Scholar 

  • Kuhad A, Chopra K (2007) Curcumin attenuates diabetic encephalopathy in rats: behavioral and iochemical evidences. Eur J Pharmacol 576(1–3):34–42, PMID: 17822693

    Article  PubMed  CAS  Google Scholar 

  • Laso FJ, Vaquero JM, Almeida J, Marcos M, Orfao A (2007) Chronic alcohol consumption is associated with changes in the distribution, immunophenotype, and the inflammatory cytokine secretion profile of circulating dendritic cells. Alcohol Clin Exp Res 31(5):846–854, Epub ahead of print Mar 26 PMID: 17386065

    Article  PubMed  CAS  Google Scholar 

  • Lata J, Novotný I, Príbramská V, Juránková J, Fric P, Kroupa R et al (2007) The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study. Eur J Gastroenterol Hepatol 19(12):1111–1113, PMID: 17998837

    Article  PubMed  Google Scholar 

  • Levitzky YS, Guo CY, Rong J, Larson MG, Walter RE, Keaney JF Jr, et al (2008) Relation of smoking status to a panel of inflammatory markers: The Framingham offspring. Atherosclerosis Epub ahead of print Feb 18 PMID: 18289552

  • Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM (2004) Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 39(5):1441–1449, PMID: 15122774

    Article  PubMed  Google Scholar 

  • Loguercio C, Federico A, Tuccillo C, Terracciano F, D’Auria MV, De Simone C et al (2005) Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J Clin Gastroenterol 39(6):540–543, PMID: 15942443

    Article  PubMed  Google Scholar 

  • Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA (2007) Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 52(11):3259–3565, PMID: 17393330

    Article  PubMed  Google Scholar 

  • Malekinejad H, Scherpenisse P, Bergwerff AA (2006) Naturally occurring estrogens in processed milk and in raw milk (from gestated cows). J Agric Food Chem 54(26):9785–9791, PMID: 17177502

    Article  PubMed  CAS  Google Scholar 

  • Müller M, Lier D (1994) Fermentation of fructans by epiphytic lactic acid bacteria. J Appl Bacteriol 76(4):406–411, PMID: 8200866

    PubMed  Google Scholar 

  • Naaber P, Smidt I, Stsepetova J, Brilene T, Annuk H, Mikelsaar M (2004) Inhibition of Clostridium difficile strains by intestinal Lactobacillus species. J Med Microbiol 53(Pt 6):551–554, PMID: 15150337

    Article  PubMed  Google Scholar 

  • Nagler-Anderson C (2000) Tolerance and immunity in the intestinal immune system. Crit Rev Immunol 20(2):103–20, PMID: 10872893

    PubMed  CAS  Google Scholar 

  • Outwater JL, Nicholson A, Barnard N (1997) Dairy products and breast cancer: the IGF-I, estrogen, and bGH hypothesis. Med Hypotheses 48(6):453–461, PMID: 9247884

    Article  PubMed  CAS  Google Scholar 

  • Ouwehand AC, Salminen S, Isolauri E (2002) Probiotics: an overview of beneficial effects. Antonie Van Leeuwenhoek 82(1–4):279–289, PMID: 12369194

    Article  PubMed  CAS  Google Scholar 

  • Pancer Z, Cooper MD (2006) The evolution of adaptive immunity. Annu Rev Immunol 24:497–518, PMID: 16551257

    Article  PubMed  CAS  Google Scholar 

  • Prioult G, Fliss I, Pecquet S (2003) Effect of probiotic bacteria on induction and maintenance of oral tolerance to beta-lactoglobulin in gnotobiotic mice. Clin Diagn Lab Immunol 10(5):787–792, PMID: 12965905

    Article  PubMed  CAS  Google Scholar 

  • Rayes N, Seehofer D, Theruvath T, Schiller RA, Langrehr JM, Jonas S et al (2005) Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation—a randomized, double-blind trial. Am J Transplant 5(1):125–130, PMID: 15636620

    Article  PubMed  Google Scholar 

  • Reddy GK (2004) Cross-linking in collagen by nonenzymatic glycation increases the matrix stiffness in rabbit achilles tendon. Exp Diabesity Res 5(2):143–53, PMID: 15203885

    Article  PubMed  CAS  Google Scholar 

  • Riordan SM, Skinner NA, McIver CJ, Liu Q, Bengmark S, Bihari D, Visvanathan K (2007) Synbiotic-associated improvement in liver function in cirrhotic patients: Relation to changes in circulating cytokine messenger RNA and protein levels. Microb Ecol Health Dis 19:7–16

    Article  CAS  Google Scholar 

  • Sebeková K, Krajcoviová-Kudlácková M, Schinzel R, Faist V, Klvanová J, Heidland A (2001) Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet. 240(6):275–81, PMID: 11876491

  • Sebeková K, Kupcová V, Schinzel R, Heidland A (2002) Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis—amelioration by liver transplantation. J Hepatol 36(1):66–71, PMID: 11804666

    Article  PubMed  Google Scholar 

  • Stadlbauer V, Mookerjee RP, Hodges S, Wright GA, Davies NA, Jalan R (2007) Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol 48(6):945–951, PMID: 18433921

    Article  CAS  Google Scholar 

  • Solga SF, Diehl AM (2004) Gut flora-based therapy in liver disease? The liver cares about the gut. Hepatology 39(5):1197–1200, PMID: 15122746

    Article  PubMed  Google Scholar 

  • Suzuki C, Kimoto-Nira H, Kobayashi M, Nomura M, Sasaki K, Mizumachi K (2008) Immunomodulatory and cytotoxic effects of various Lactococcus strains on the murine macrophage cell line J774.1. Int J Food Microbiol 123(1–2):159–165, PMID: 18258324

    Article  PubMed  CAS  Google Scholar 

  • Tabak C, Arts IC, Smit HA, Heederik D, Kromhout D (2001) Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. Am J Respir Crit Care Med 164(1):61–64, PMID: 11435239

    PubMed  CAS  Google Scholar 

  • Taneja R, Parodo J, Jia SH, Kapus A, Rotstein OD, Marshall JC (2004) Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 32(7):1460–1469, PMID: 15241089

    Article  PubMed  CAS  Google Scholar 

  • Tlaskalová-Hogenová H, Stepánková R, Hudcovic T, Tucková L, Cukrowska B, Lodinová-Zádníková R et al (2004) Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett 93(2–3):97–108, PMID: 15158604

    Article  PubMed  CAS  Google Scholar 

  • Tok D, Ilkgul O, Bengmark S, Aydede H, Erhan Y, Taneli F et al (2007) Pretreatment with pro- and synbiotics reduces peritonitis-induced acute lung injury in rats. J Trauma 62(4):880–885, PMID: 17426542

    Article  PubMed  Google Scholar 

  • Tucker KL, Morita K, Qiao N, Hannan MT, Cupples LA, Kiel DP (2006) Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study. Am J Clin Nutr 84(4):936–942, PMID: 17023723

    PubMed  CAS  Google Scholar 

  • van Tongeren SP, Slaets JP, Harmsen HJ, Welling GW (2005) Fecal microbiota composition and frailty. Appl Environ Microbiol 71(10):6438–6442, PMID: 16204576

    Article  PubMed  CAS  Google Scholar 

  • Vasto S, Malavolta M, Pawelec G (2006) Age and immunity. Immun Ageing 3:2, Feb 24, PMID: 16504129

    Article  PubMed  CAS  Google Scholar 

  • Verdú EF, Bercík P, Bergonzelli GE, Huang XX, Blennerhasset P, Rochat F et al (2004) Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Gastroenterology 127(3):826–837, PMID: 15362038

    Article  PubMed  CAS  Google Scholar 

  • von der Weid T, Bulliard C, Schiffrin EJ (2001) Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10. Clin Diagn Lab Immunol 8(4):695–701, PMID: 11427413

    Article  Google Scholar 

  • Wolford ST, Argoudelis CJ (1979) Measurement of estrogens in cow’s milk, human milk, and dairy products. J Dairy Sci 62(9):1458–1463, PMID: 512140

    Article  PubMed  CAS  Google Scholar 

  • Woodmansey EJ (2007) Intestinal bacteria and ageing. J Appl Microbiol 102(5):1178–1186, PMID: 17448153

    Article  PubMed  CAS  Google Scholar 

  • Yagmur E, Tacke F, Weiss C, Lahme B, Manns MP, Kiefer P et al (2006) Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin Biochem 39(1):39–45, PMID: 16321365

    Article  PubMed  CAS  Google Scholar 

  • Zittermann A, Schleithoff SS, Koerfer R (2005) Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 94(4):483–92, PMID: 16197570

    Article  PubMed  CAS  Google Scholar 

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Bengmark, S. Bio-ecological control of chronic liver disease and encephalopathy. Metab Brain Dis 24, 223–236 (2009). https://doi.org/10.1007/s11011-008-9128-z

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