Abstract
Introduction: Hepatic encephalopathy is a neurologic syndrome secondary to liver failure that causes cognitive and motor abnormalities. Impairment in the function of the first neuron of the motor tract (corticospinal tract) has been demonstrated in patients with cirrhosis and minimal hepatic encephalopathy. Aim: Investigate the function of the first neuron of the motor tract in experimental models of minimal hepatic encephalopathy. Material and methods: Rats with portocaval anastomosis (n=8) and rats with carbon tetrachloride induced cirrhosis (n=11) underwent neurophysiological recording under light anesthesia with propofol. Motor evoked potentials were elicited applying a transcranial electric pulse and were recorded in the tibialis anterior muscle. The effect of the dose of anesthesia was assessed in a group of normal rats (n=10). Results: Rats with portocaval anastomosis exhibited a decrease in motor evoked potentials amplitude following surgery (67±11 to 41±16%, P < 0.001). Cirrhotic rats exhibited an increase in motor evoked potentials latency after the appearance of ascites (4.65±0.43 to 5.15±0.67 ms., P=0.04). Increasing doses of propofol produced a decrease in the amplitude and an increase in the latency of motor evoked potentials. Conclusion: It is possible to reproduce functional abnormalities of the central motor tract in rats with portocaval anastomosis and carbon tetrachloride induced cirrhosis. The development of motor abnormalities in experimental models of minimal hepatic encephalopathy offers the possibility to investigate the mechanisms involved in the pathogenesis of hepatic encephalopathy and test therapeutic strategies.
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Acknowledgments
Study supported by Instituto de Salud Carlos III (C03/02; G03/155; FIS 05-1109; FIS 05-900). NC is a recipient of intraeuropean Marie Curie fellowship (2005-515397).
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Oria, M., Raguer, N., Chatauret, N. et al. Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis. Metab Brain Dis 21, 297–308 (2006). https://doi.org/10.1007/s11011-006-9036-z
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DOI: https://doi.org/10.1007/s11011-006-9036-z