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Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients

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Abstract

Factor XIII (FXIII) stabilizes and protects the fibrin network. Its role in myocardial infarction (MI) is still to be clarified. To evaluate the association of FXIII levels with MI in young patients and to investigate how the FXIII-A p.Val34Leu, FXIII-B p.His95Arg, and IVS11, c.1952 + 144 C>G (Intron K) polymorphisms influence FXIII levels and MI risk. Patients with ST elevation MI below 40 years of age (MI, n = 119), age-matched clinical controls (CC, n = 101) without MI and coronary artery disease, and healthy controls (HC, n = 120) were investigated for FXIII activity, FXIII-A2B2, FXIII-B concentrations and for the polymorphisms. FXIII activity and FXIII-A2B2 antigen were significantly elevated in MI. FXIII activity and antigen were significantly elevated in Arg95, while decreased in Intron K “G” carriers. Smoking had an independent increasing effect on FXIII activity and FXIII-A2B2 antigen. Intron K C>G polymorphism significantly decreased the risk of MI in patients with elevated fibrinogen. Among the investigated factors Intron K C>G polymorphism and smoking have the most powerful effect on FXIII levels and on the risk of MI in the young. The effect of smoking on coronary thrombus formation may partially be attributed to its FXIII increasing effect.

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Acknowledgements

The study was supported by Grants from the National Research, Development and Innovation Fund (K 113097, K 109783, and K 116228) from the Hungarian Academy of Sciences (MTA 11003 TKI417) and from the University of Debrecen, Faculty of Medicine, and by the EFOP-3.6.2-16-2017-00006 project. The project is co-financed by the European Union and the European Social Fund.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, University of Debrecen, 22, Móricz Zs. krt., Debrecen, 4032, Hungary

    László Balogh & István Édes

  2. Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98, Nagyerdei krt., Debrecen, 4032, Hungary

    Éva Katona, Zoltán A. Mezei, Judit Kállai, Réka Gindele, László Muszbek & Zsuzsanna Bereczky

  3. Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 22, Móricz Zs. krt., Debrecen, 4032, Hungary

    Zoltán Papp

  4. Vascular Biology, Thrombosis and Hemostasis Research Group of the Hungarian Academy of Sciences, University of Debrecen, 98, Nagyerdei krt., Debrecen, 4032, Hungary

    László Muszbek

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  1. László Balogh
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Correspondence to László Balogh.

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Balogh, L., Katona, É., Mezei, Z.A. et al. Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients. Mol Cell Biochem 448, 199–209 (2018). https://doi.org/10.1007/s11010-018-3326-8

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