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Detraining reverses exercise-induced improvement in blood pressure associated with decrements of oxidative stress in various tissues in spontaneously hypertensive rats

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Abstract

This study aimed to investigate the effects of moderate intensity swimming exercise (10 weeks) followed by detraining (for five and 10 weeks) on oxidative stress levels of heart, lung, kidney, and liver tissues and systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR). SHR and control rats were randomized into sedentary, exercised, detrained (5 weeks) and late-detrained (10 weeks) groups. Corresponding sedentary rats were grouped as time 1-2-3. Exercise of 60 min, 5 days/week/10 weeks was applied. Detraining rats underwent the same training protocol and then discontinued training during next 5, 10 weeks. SBP was measured by tail-cuff method. Tissue total oxidant/antioxidant status was measured using a commercial kit and oxidative stress index (OSI) was calculated. Exercise training slightly decreased tissue OSI of SHR and reduced SBP of both groups. Tissue OSI of SHR were higher than WKY and aging resulted in increment of oxidants in groups. detraining yielded time-dependent increments in oxidative stress of all tissues and SBP of both rat groups. Although short-term cessations may be tolerated, our results emphasize the importance of exercising as a way of life for cardiovascular well-being in hypertensives or in individuals who are genetically under risk of hypertension.

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Acknowledgments

This study was supported by Pamukkale University Scientific Research Projects Coordination Unit through project numbers 2012ARŞ002, 2013SBE002, 2013SBE003, and 2015HZL010.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Physiology, Pamukkale University, Kinikli, 20070, Denizli, Turkey

    Ozgen Kilic-Erkek, Sadettin Caliskan, Yusuf Ekbic, Vural Kucukatay & Melek Bor-Kucukatay

  2. Denizli Health Services Vocational High School, Department of Physiotherapy, Pamukkale University, Kinikli, Denizli, Turkey

    Emine Kilic-Toprak

  3. Faculty of Medicine, Department of Internal Medicine, Erciyes University, Kayseri, Turkey

    Ismail Hakki Akbudak

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  1. Ozgen Kilic-Erkek
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  2. Emine Kilic-Toprak
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  6. Vural Kucukatay
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Correspondence to Melek Bor-Kucukatay.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Kilic-Erkek, O., Kilic-Toprak, E., Caliskan, S. et al. Detraining reverses exercise-induced improvement in blood pressure associated with decrements of oxidative stress in various tissues in spontaneously hypertensive rats. Mol Cell Biochem 412, 209–219 (2016). https://doi.org/10.1007/s11010-015-2627-4

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