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4G/5G polymorphism modulates PAI-1 circulating levels in obese women

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Abstract

The increase in plasminogen activator inhibitor type 1 (PAI-1) has been described as a risk factor to thrombosis-related diseases. In addition, it has been demonstrated that the variant 4G of polymorphism 4G/5G located in promoter region of PAI-1 gene is associated with higher PAI-1 levels. We investigate the role of this polymorphism on circulating PAI-1 concentration in a population of 57 obese women (23%, 4G/4G; 49%, 4G/5G and 28%, 5G/5G genotypes). Our results demonstrate a genotype-specific modulation on PAI-1 levels in obese women, thus 5G/5G genotype presented significantly lower levels of plasma PAI-1 when compared to 4G/4G group (46 ± 19 ng/mL vs. 63  ± 13 ng/mL, respectively). Our findings indicate that obese carriers of 4G/4G genotype may have increased risk to develop thrombotic diseases.

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  1. Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, MG, Brazil

    Karla S. Fernandes & Valéria C. Sandrim

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  1. Karla S. Fernandes
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  2. Valéria C. Sandrim
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Correspondence to Valéria C. Sandrim.

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Fernandes, K.S., Sandrim, V.C. 4G/5G polymorphism modulates PAI-1 circulating levels in obese women. Mol Cell Biochem 364, 299–301 (2012). https://doi.org/10.1007/s11010-012-1230-1

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  • DOI: https://doi.org/10.1007/s11010-012-1230-1

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