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Potential role of calcineurin in pathogenic conditions

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Abstract

Since its initial discovery as Ca2+/calmodulin (CaM)-dependent serine/threonine protein phosphatase, calcineurin (CaN) has been extensively studied in many mammalian tissues. CaN has been shown to be involved in various biological and Ca2+-dependent signal transduction pathways. Over the last decade, our laboratory has been interested and has carried out numerous experiments on this specific protein phosphatase. While, a lot of research has been performed studying CaN’s involvement in ischemia, the immune system, and various mammalian tissues, not much is known about the potential role of CaN in various eye diseases. This review focuses on the studies that have been carried out in our laboratory on CaN, and specifically CaN’s involvement in the eye. We demonstrated that CaN is localized in various eye tissues (cornea, iris, ciliary body, vitreous body, retina, choroid, sclera, and optic nerve) and that both its protein expression and activity were observed in high amounts in the retina, optic nerve and cornea. Recently, we have cloned and characterized the CaN A and B subunits in the bovine retina. These initial findings suggest that CaN may play a potential role in visual transduction and various ocular diseases, including cancer.

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Acknowledgments

This review is supported by the College of Medicine, University of Saskatchewan, Canada. The authors are thankful to Dr. Anuraag Shrivastav, Research Division, Saskatchewan Cancer Agency, Saskatoon, SK, for his suggestions and helpful discussion regarding this paper. Authors are thankful to the Association for Research in Vision and Ophthalmology for their permission to use some of the figures used in this article.

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  1. Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Khaliq Kurji & Rajendra K. Sharma

  2. Research Division, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan, S7N 4H4, Canada

    Khaliq Kurji & Rajendra K. Sharma

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Kurji, K., Sharma, R.K. Potential role of calcineurin in pathogenic conditions. Mol Cell Biochem 338, 133–141 (2010). https://doi.org/10.1007/s11010-009-0346-4

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