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Ca2+-modulated vision-linked ROS-GC guanylate cyclase transduction machinery

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Abstract

Vertebrate phototransduction depends on the reciprocal relationship between two-second messengers, cyclic GMP and Ca2+. The concentration of both is reciprocally regulated including the dynamic synthesis of cyclic GMP by a membrane bound guanylate cyclase. Different from hormone receptor guanylate cyclases, the cyclases operating in phototransduction are regulated by the intracellular Ca2+-concentration via small Ca2+-binding proteins. Based on the site of their expression and their Ca2+ modulation, this sub-branch of the cyclase family was named sensory guanylate cyclases, of which the retina specific forms are named ROS-GCs (rod outer segment guanylate cyclases). This review focuses on the structure and function of the ROS-GC subfamily present in the mammalian retinal neurons: photoreceptors and inner layers of the retinal neurons. Portions and excerpts of the review are from a previous chapter (Curr Top Biochem Res 6:111–144, 2004).

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Acknowledgments

This research was supported by several grants of the Deutsche Forschungsgemeinschaft (K.-W. Koch) and USPHS awards DC 005349 (RKS), HL084584 (TD).

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  1. AG Biochemistry, IBU, Faculty V, Carl von Ossietzky University, Oldenburg, 26111, Germany

    Karl-W. Koch

  2. Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA, 19027, USA

    Teresa Duda & Rameshwar K. Sharma

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  1. Karl-W. Koch
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Correspondence to Rameshwar K. Sharma.

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Koch, KW., Duda, T. & Sharma, R.K. Ca2+-modulated vision-linked ROS-GC guanylate cyclase transduction machinery. Mol Cell Biochem 334, 105–115 (2010). https://doi.org/10.1007/s11010-009-0330-z

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