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Diversity of sensory guanylate cyclases in teleost fishes

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Abstract

Teleost fishes like medaka fish (Oryzias latipes), zebrafish (Danio rerio), and pufferfish (Fugu rubripes) contain in their genomes a larger number of guanylate cyclases and guanylate cyclase-activating proteins than mammals. Based on amino acid sequence alignments a group of transmembrane sensory guanylate cyclases can be identified, which are mainly if not exclusively expressed in sensory organs like the retina and olfactory tissue. Retina specific guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish show dynamic changes in their spatial–temporal expression patterns and transcripts of the corresponding genes appear coincidently with the beginning of cone cell maturation at 3 days post-fertilization. Expression patterns of the guanylate cyclase signaling systems during larval development are correlated with the special habitat challenges of zebrafishes in the wild.

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Acknowledgment

Experimental work in the laboratory of the corresponding author (K.-W.K.) is supported by a grant from the Deutsche Forschungsgemeinschaft (Ko948/7-1/7-2).

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  1. Biochemistry Group, Institute of Biology and Environmental Science, Faculty V, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany

    Nina Rätscho, Alexander Scholten & Karl-Wilhelm Koch

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  1. Nina Rätscho
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  2. Alexander Scholten
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  3. Karl-Wilhelm Koch
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Correspondence to Karl-Wilhelm Koch.

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Rätscho, N., Scholten, A. & Koch, KW. Diversity of sensory guanylate cyclases in teleost fishes. Mol Cell Biochem 334, 207–214 (2010). https://doi.org/10.1007/s11010-009-0320-1

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