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Association between manganese superoxide dismutase (MnSOD) gene polymorphism and elderly obesity

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Abstract

Evidence suggests an association between obesity and oxidative stress caused by superoxide production. Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. We analyzed 815 free-living community subjects (≥60 years old) grouped into subjects who were either obese (BMI ≥ 30 kg/m2) or non-obese (BMI < 25 kg/m2). Additionally, we investigated the possible interaction between the Ala16Val MnSOD gene polymorphism and obesity in the modulation of biochemical and nutritional variables. We found a positive association between MnSOD polymorphism and obesity, since higher VV frequency (28.2%) was observed in the obese group (P = 0.002, odds ratio 1.949, 95% CI: 1.223–3.008). This result was independent of sex, age, diabetes, dyslipidemia, hypertension, and metabolic syndrome. A possible biological explanation of the association described here could be a chronic state of superoxide enzyme imbalance present in VV carriers, which could affect differential metabolic pathways contributing to the obese state.

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Acknowledgments

The authors thank the team of Project Genesis and Prefeitura Municipal de Gravatai for helping in data collection and CNPq (No. 471233/2007-2, No. 311231/2006-3), CAPES and FAPERGS for grants and fellowships. Dr. A. Leyva provided English editing of the manuscript.

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Authors and Affiliations

  1. Programa de Doctorado en Biomedicina, Departamento de Ciencias Biomedicas, Universidad de Leon, Leon, Spain

    Marco Aurélio Echart Montano & Juan Pablo Barrio Lera

  2. Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Algre, Brazil

    Maria Gabriela Valle Gottlieb & Carla Helena Augustin Schwanke

  3. Instituto de Geriatria e Gerontologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Algre, Brazil

    Carla Helena Augustin Schwanke

  4. Laboratório de Biogenômica do Desenvolvimento, Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000, Prédio 19, Santa Maria, RS, CEP 97.900-105, Brazil

    Maria Izabel Ugalde Marques da Rocha, Maria Fernanda Manica-Cattani & Ivana Beatrice Manica da Cruz

  5. Programa de Pós-Graduação em Ciências Biológicas (Bioquímica Toxicológica), Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil

    Greice Feyl dos Santos & Ivana Beatrice Manica da Cruz

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  1. Marco Aurélio Echart Montano
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  2. Juan Pablo Barrio Lera
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  8. Ivana Beatrice Manica da Cruz
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Correspondence to Ivana Beatrice Manica da Cruz.

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Montano, M.A.E., Barrio Lera, J.P., Gottlieb, M.G.V. et al. Association between manganese superoxide dismutase (MnSOD) gene polymorphism and elderly obesity. Mol Cell Biochem 328, 33–40 (2009). https://doi.org/10.1007/s11010-009-0071-z

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  • DOI: https://doi.org/10.1007/s11010-009-0071-z

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