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Cyclin D1 (G870A) polymorphism and risk of cervix cancer: a case control study in north Indian population

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Abstract

Cyclin D1 (CCND1) is a key regulatory protein, playing a critical role in the transition from G1 to S phase of the cell cycle. We have evaluated the association between CCND1 A870G polymorphism and risk of cervix cancer in north Indian women by using PCR–RFLP method. This association was estimated by computing odds ratio (ORs) and a 95% Confidence Intervals (95% CI) using a Multivariate Logistic Regression Analysis. No significant association was observed between CCND1 genotypes and overall risk of cervix cancer. But when stratified histologically, statistically significant (OR: 3.7, 95% CI: 1.56–8.87, P: 0.001) increased risk of squamous cell carcinoma (SCC) was observed for individuals with AA genotype. Thus our findings suggest that CCND1 (G870A) polymorphism may be associated with increased risk of SCC of the uterine cervix in north Indian women.

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Acknowledgments

The authors wish to thank all the staff and the patients who took part in this study. The work was funded by Council for Scientific and Industrial Research, New Delhi, India.

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Authors and Affiliations

  1. Department of Biotechnology, Panjab University, Chandigarh, 160014, India

    Kaur Satinder, Sobti Ranbir Chander & Kaur Pushpinder

  2. Department of Gynecology, PGIMER, Chandigarh, 160014, India

    Gupta Indu

  3. Department of Gynecology, Mohan Dai Oswal Cancer Hospital, Ludhiana, Punjab, India

    Jain Veena

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  1. Kaur Satinder
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Correspondence to Kaur Satinder.

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Satinder, K., Chander, S.R., Pushpinder, K. et al. Cyclin D1 (G870A) polymorphism and risk of cervix cancer: a case control study in north Indian population. Mol Cell Biochem 315, 151–157 (2008). https://doi.org/10.1007/s11010-008-9799-0

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